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GeneID |
1812
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Symbol |
DRD1
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Synonyms |
DADR|DRD1A
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Description |
dopamine receptor D1 |
See related |
HGNC:3020|MIM:126449|Ensembl:ENSG00000184845|HPRD:00538| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
5q35.1 |
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Gene set name |
Method of gene set |
Evidence |
Info |
GSMA_IIA | genome scan meta-analysis (All samples) | Psr: 0.0276 | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
C5orf42 | 0.78 | 0.80 | | |
AADAT | 0.77 | 0.76 | | |
TCTN2 | 0.77 | 0.74 | | |
KCTD3 | 0.76 | 0.80 | | |
PROM1 | 0.75 | 0.75 | | |
ZC3H7A | 0.74 | 0.81 | | |
REV3L | 0.74 | 0.82 | | |
MGEA5 | 0.74 | 0.78 | | |
TOR1B | 0.74 | 0.76 | | |
BIVM | 0.72 | 0.77 | | |
Top 10 negatively co-expressed genes | REEP6 | -0.54 | -0.49 | | |
AF347015.31 | -0.54 | -0.65 | | |
MT-CO2 | -0.53 | -0.65 | | |
AF347015.27 | -0.53 | -0.62 | | |
TSC22D4 | -0.52 | -0.56 | | |
IFI27 | -0.51 | -0.62 | | |
CA4 | -0.51 | -0.54 | | |
FXYD1 | -0.51 | -0.59 | | |
AF347015.33 | -0.51 | -0.60 | | |
AIFM3 | -0.51 | -0.51 | | |
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Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0001590 | dopamine D1 receptor activity | IEA | dopamine (GO term level: 10) | - |
GO:0004872 | receptor activity | IEA | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007416 | synaptogenesis | ISS | Synap (GO term level: 6) | - |
GO:0060158 | dopamine receptor, phospholipase C activating pathway | IGI | dopamine (GO term level: 10) | 17194762 |
GO:0051584 | regulation of dopamine uptake | IC | Synap, Neurotransmitter, dopamine (GO term level: 11) | 8301582 |
GO:0051968 | positive regulation of synaptic transmission, glutamatergic | ISS | neuron, glutamate, Synap, Neurotransmitter (GO term level: 10) | - |
GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | IEA | dopamine (GO term level: 12) | - |
GO:0019226 | transmission of nerve impulse | IEA | neuron (GO term level: 5) | - |
GO:0021853 | cerebral cortex GABAergic interneuron migration | IEA | neuron, GABA (GO term level: 14) | - |
GO:0042053 | regulation of dopamine metabolic process | IEA | dopamine (GO term level: 9) | - |
GO:0001975 | response to amphetamine | IEA | | - |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | IDA | | 1282671 |
GO:0007165 | signal transduction | IEA | | - |
GO:0008542 | visual learning | IEA | | - |
GO:0010580 | activation of adenylate cyclase activity involved in G-protein signaling | IDA | | 2144334 |
GO:0007631 | feeding behavior | IEA | | - |
GO:0007628 | adult walking behavior | IEA | | - |
GO:0007626 | locomotory behavior | IEA | | - |
GO:0007625 | grooming behavior | IEA | | - |
GO:0007617 | mating behavior | IEA | | - |
GO:0042493 | response to drug | IEA | | - |
GO:0030432 | peristalsis | IEA | | - |
GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | IDA | | 1282671 |7838121 |
GO:0030819 | positive regulation of cAMP biosynthetic process | IDA | | 1282671 |7838121 |
GO:0030335 | positive regulation of cell migration | IEA | | - |
GO:0043268 | positive regulation of potassium ion transport | ISS | | - |
GO:0051482 | elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | IDA | | 1282671 |
GO:0060134 | prepulse inhibition | IEA | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0005789 | endoplasmic reticulum membrane | IEA | | - |
GO:0005624 | membrane fraction | IEA | | - |
GO:0005783 | endoplasmic reticulum | IEA | | - |
GO:0005886 | plasma membrane | IDA | | 11500503 |
GO:0005887 | integral to plasma membrane | IC | | 2144334 |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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