Gene Page: DRD1

Summary
GeneID  1812
Symbol  DRD1
Synonyms  DADR|DRD1A
Description  dopamine receptor D1
See related  HGNC:3020|MIM:126449|Ensembl:ENSG00000184845|HPRD:00538|
Locus tag  -
Gene type  protein-coding
Map location  5q35.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C5orf420.780.80
AADAT0.770.76
TCTN20.770.74
KCTD30.760.80
PROM10.750.75
ZC3H7A0.740.81
REV3L0.740.82
MGEA50.740.78
TOR1B0.740.76
BIVM0.720.77
Top 10 negatively co-expressed genes
REEP6-0.54-0.49
AF347015.31-0.54-0.65
MT-CO2-0.53-0.65
AF347015.27-0.53-0.62
TSC22D4-0.52-0.56
IFI27-0.51-0.62
CA4-0.51-0.54
FXYD1-0.51-0.59
AF347015.33-0.51-0.60
AIFM3-0.51-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001590dopamine D1 receptor activityIEAdopamine (GO term level: 10)-
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisISSSynap (GO term level: 6)-
GO:0060158dopamine receptor, phospholipase C activating pathwayIGIdopamine (GO term level: 10)17194762 
GO:0051584regulation of dopamine uptakeICSynap, Neurotransmitter, dopamine (GO term level: 11)8301582 
GO:0051968positive regulation of synaptic transmission, glutamatergicISSneuron, glutamate, Synap, Neurotransmitter (GO term level: 10)-
GO:0007191dopamine receptor, adenylate cyclase activating pathwayIEAdopamine (GO term level: 12)-
GO:0019226transmission of nerve impulseIEAneuron (GO term level: 5)-
GO:0021853cerebral cortex GABAergic interneuron migrationIEAneuron, GABA (GO term level: 14)-
GO:0042053regulation of dopamine metabolic processIEAdopamine (GO term level: 9)-
GO:0001975response to amphetamineIEA-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerIDA1282671 
GO:0007165signal transductionIEA-
GO:0008542visual learningIEA-
GO:0010580activation of adenylate cyclase activity involved in G-protein signalingIDA2144334 
GO:0007631feeding behaviorIEA-
GO:0007628adult walking behaviorIEA-
GO:0007626locomotory behaviorIEA-
GO:0007625grooming behaviorIEA-
GO:0007617mating behaviorIEA-
GO:0042493response to drugIEA-
GO:0030432peristalsisIEA-
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA1282671 |7838121 
GO:0030819positive regulation of cAMP biosynthetic processIDA1282671 |7838121 
GO:0030335positive regulation of cell migrationIEA-
GO:0043268positive regulation of potassium ion transportISS-
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA1282671 
GO:0060134prepulse inhibitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIDA11500503 
GO:0005887integral to plasma membraneIC2144334 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADA-adenosine deaminase-HPRD,BioGRID12150791 
ADORA1RDC7adenosine A1 receptor-HPRD,BioGRID10890919 
CALYDRD1IP | NSG3calcyon neuron-specific vesicular protein-HPRD11583808 
COPGCOPG1 | FLJ21068coatomer protein complex, subunit gamma-HPRD,BioGRID11893085 
COPG22-COP | DKFZp761N09121 | FLJ11781coatomer protein complex, subunit gamma 2-HPRD,BioGRID11893085 
DNAJC14DNAJ | DRIP78 | HDJ3 | LIP6DnaJ (Hsp40) homolog, subfamily C, member 14-HPRD,BioGRID11331877 |14993367 
EPB41L24.1-G | DKFZp781D1972 | DKFZp781H1755erythrocyte membrane protein band 4.1-like 2-HPRD12181426 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD12408866 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY 1717All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497117123m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-203.1106010661Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-216693699m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-293803861Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-496102810341Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-500423429m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
miR-539105510611Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-93.hd/291-3p/294/295/302/372/373/520654660m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.