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| GeneID |
1814
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| Symbol |
DRD3
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| Synonyms |
D3DR|ETM1|FET1|MGC149204|MGC149205
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| Description |
dopamine receptor D3 |
| See related |
HGNC:3024|MIM:126451|Ensembl:ENSG00000151577|HPRD:00540| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
3q13.3 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 3 | Link to SZGene | | GSMA_IIE | genome scan meta-analysis (European-ancestry samples) | Psr: 0.04359 | | | GSMA_IIA | genome scan meta-analysis (All samples) | Psr: 0.04047 | | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0219 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| AFF3 | 0.93 | 0.89 | | |
| MFHAS1 | 0.92 | 0.91 | | |
| GRIK3 | 0.91 | 0.92 | | |
| LIMCH1 | 0.91 | 0.85 | | |
| DOPEY2 | 0.90 | 0.88 | | |
| ITSN1 | 0.89 | 0.85 | | |
| FAM59A | 0.89 | 0.88 | | |
| TIAM2 | 0.89 | 0.83 | | |
| TSHZ3 | 0.89 | 0.86 | | |
| EML1 | 0.89 | 0.87 | | |
Top 10 negatively co-expressed genes | | SERPINB6 | -0.66 | -0.70 | | |
| AF347015.31 | -0.60 | -0.76 | | |
| COPZ2 | -0.59 | -0.72 | | |
| HSD17B14 | -0.59 | -0.69 | | |
| MT-CO2 | -0.59 | -0.75 | | |
| FXYD1 | -0.58 | -0.74 | | |
| HIGD1B | -0.58 | -0.75 | | |
| IFI27 | -0.58 | -0.73 | | |
| RHOC | -0.58 | -0.69 | | |
| AF347015.27 | -0.58 | -0.73 | | |
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| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0001592 | dopamine D3 receptor activity | IEA | dopamine (GO term level: 10) | - |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0005515 | protein binding | IEA | | - |
| GO:0008144 | drug binding | ISS | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060161 | positive regulation of dopamine receptor signaling pathway | IEA | dopamine (GO term level: 10) | - |
| GO:0060160 | negative regulation of dopamine receptor signaling pathway | IEA | dopamine (GO term level: 10) | - |
| GO:0048715 | negative regulation of oligodendrocyte differentiation | IEA | oligodendrocyte, Glial (GO term level: 12) | - |
| GO:0051584 | regulation of dopamine uptake | IC | Synap, Neurotransmitter, dopamine (GO term level: 11) | 8301582 |
| GO:0014059 | regulation of dopamine secretion | IEA | dopamine (GO term level: 10) | - |
| GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | IDA | dopamine (GO term level: 12) | 7907363 |18424554 |
| GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | IEA | dopamine (GO term level: 12) | - |
| GO:0042417 | dopamine metabolic process | IC | Neurotransmitter, dopamine (GO term level: 8) | 8301582 |
| GO:0002016 | regulation of blood volume by renin-angiotensin | IEA | | - |
| GO:0002031 | G-protein coupled receptor internalization | IDA | | 18424554 |
| GO:0001975 | response to amphetamine | IEA | | - |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | | - |
| GO:0007194 | negative regulation of adenylate cyclase activity | IDA | | 7907363 |
| GO:0007165 | signal transduction | IEA | | - |
| GO:0008542 | visual learning | IEA | | - |
| GO:0007626 | locomotory behavior | IEA | | - |
| GO:0006874 | cellular calcium ion homeostasis | IDA | | 7911712 |
| GO:0042493 | response to drug | ISS | | - |
| GO:0050883 | musculoskeletal movement, spinal reflex action | IEA | | - |
| GO:0019216 | regulation of lipid metabolic process | IEA | | - |
| GO:0030814 | regulation of cAMP metabolic process | IDA | | 8666994 |
| GO:0032922 | circadian regulation of gene expression | IEA | | - |
| GO:0043278 | response to morphine | IEA | | - |
| GO:0040014 | regulation of multicellular organism growth | IEA | | - |
| GO:0045840 | positive regulation of mitosis | ISS | | - |
| GO:0048148 | behavioral response to cocaine | IEA | | - |
| GO:0050709 | negative regulation of protein secretion | IDA | | 16839358 |
| GO:0050482 | arachidonic acid secretion | IDA | | 8301582 |
| GO:0045776 | negative regulation of blood pressure | IEA | | - |
| GO:0045471 | response to ethanol | IEA | | - |
| GO:0051898 | negative regulation of protein kinase B signaling cascade | IEA | | - |
| GO:0060134 | prepulse inhibition | IMP | | 18325483 |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005624 | membrane fraction | IEA | | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0005887 | integral to plasma membrane | IC | | 8301582 |
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