Gene Page

Gene Page: ATN1

Summary

GeneID

1822

Symbol

ATN1

Synonyms

B37|D12S755E|DRPLA|NOD

Description

atrophin 1

Locus tag

Gene type

protein-coding

Map location

12p13.31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2088

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003714

transcription corepressor activity

IEA

GO:0005515

protein binding

IEA

GO:0019904

protein domain specific binding

IPI

11984006

GO:0050827

toxin receptor binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007417

central nervous system development

TAS

Brain (GO term level: 6)

7647802

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

IEA

GO:0008219

cell death

IEA

GO:0009404

toxin metabolic process

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

10814707

GO:0005737

cytoplasm

IEA

GO:0005737

cytoplasm

TAS

7647802

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	-	HPRD	14645126
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD,BioGRID	10332026
CASP1	ICE \| IL1BC \| P45	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Atrophin-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 1 from an unspecified species.	BIND	9535906
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	Atrophin-1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 3 from an unspecified species.	BIND	9535906
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	Atrophin-1 interacts with caspase 7.	BIND	9535906
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Atrophin-1 interacts with caspase 8.	BIND	9535906
CTNND2	GT24 \| NPRAP	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	Two-hybrid	BioGRID	10332026
DVL1	DVL \| MGC54245	dishevelled, dsh homolog 1 (Drosophila)	Two-hybrid	BioGRID	10332026
ITCH	AIF4 \| AIP4 \| NAPP1 \| dJ468O1.1	itchy E3 ubiquitin protein ligase homolog (mouse)	-	HPRD,BioGRID	9647693
ITCH	AIF4 \| AIP4 \| NAPP1 \| dJ468O1.1	itchy E3 ubiquitin protein ligase homolog (mouse)	Atrophin-1 interacts with AIP4.	BIND	9647693
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MAGI1	AIP3 \| BAIAP1 \| BAP1 \| MAGI-1 \| TNRC19 \| WWP3	membrane associated guanylate kinase, WW and PDZ domain containing 1	Atrophin-1 interacts with AIP-3.	BIND	9647693
MAGI1	AIP3 \| BAIAP1 \| BAP1 \| MAGI-1 \| TNRC19 \| WWP3		-	HPRD,BioGRID	9647693
MAGI2	ACVRIP1 \| AIP1 \| ARIP1 \| MAGI-2 \| SSCAM	membrane associated guanylate kinase, WW and PDZ domain containing 2	Atrophin-1 interacts with AIP1.	BIND	9647693
MAGI2	ACVRIP1 \| AIP1 \| ARIP1 \| MAGI-2 \| SSCAM		-	HPRD	9647693
MYST2	HBO1 \| HBOA \| KAT7	MYST histone acetyltransferase 2	Two-hybrid	BioGRID	16169070
PDCD6IP	AIP1 \| Alix \| DRIP4 \| HP95 \| MGC17003	programmed cell death 6 interacting protein	-	HPRD,BioGRID	9647693
RERE	ARG \| ARP \| ATN1L \| DNB1 \| FLJ38775 \| KIAA0458	arginine-glutamic acid dipeptide (RE) repeats	-	HPRD,BioGRID	10814707
TLE1	ESG \| ESG1 \| GRG1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	Two-hybrid	BioGRID	16169070
VIM	FLJ36605	vimentin	Two-hybrid	BioGRID	16169070
WWP1	AIP5 \| DKFZp434D2111 \| Tiul1 \| hSDRP1	WW domain containing E3 ubiquitin protein ligase 1	-	HPRD,BioGRID	9647693
WWP1	AIP5 \| DKFZp434D2111 \| Tiul1 \| hSDRP1	WW domain containing E3 ubiquitin protein ligase 1	Atrophin-1 interacts with AIP-5.	BIND	9647693
WWP2	AIP2 \| WWp2-like	WW domain containing E3 ubiquitin protein ligase 2	Atrophin-1 interacts with AIP2.	BIND	9647693
WWP2	AIP2 \| WWp2-like	WW domain containing E3 ubiquitin protein ligase 2	-	HPRD,BioGRID	9647693

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-410	453	459	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.