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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: DVL2

Summary

GeneID

1856

Symbol

DVL2

Synonyms

Description

dishevelled, dsh homolog 2 (Drosophila)

Locus tag

Gene type

protein-coding

Map location

17p13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1522

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004871

signal transducer activity

TAS

8887313

GO:0042802

identical protein binding

IPI

16189514

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001843

neural tube closure

IEA

GO:0016055

Wnt receptor signaling pathway

IEA

GO:0007379

segment specification

IEA

GO:0007242

intracellular signaling cascade

IEA

GO:0007507

heart development

IEA

GO:0007447

imaginal disc pattern formation

TAS

8887313

GO:0007275

multicellular organismal development

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005737

cytoplasm

TAS

9192851

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP1M1	AP47 \| CLAPM2 \| CLTNM \| MU-1A	adaptor-related protein complex 1, mu 1 subunit	Two-hybrid	BioGRID	16189514
AP2M1	AP50 \| CLAPM1 \| mu2	adaptor-related protein complex 2, mu 1 subunit	Two-hybrid	BioGRID	16189514
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	Two-hybrid	BioGRID	16189514
ARRB1	ARB1 \| ARR1	arrestin, beta 1	-	HPRD,BioGRID	11742073
AXIN1	AXIN \| MGC52315	axin 1	-	HPRD,BioGRID	10829020
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	Two-hybrid	BioGRID	16189514
BAHD1	KIAA0945	bromo adjacent homology domain containing 1	Two-hybrid	BioGRID	16189514
C16orf48	DAKV6410 \| DKFZp434A1319	chromosome 16 open reading frame 48	Two-hybrid	BioGRID	16189514
C9orf100	FLJ14642 \| MGC44886 \| RP11-331F9.7	chromosome 9 open reading frame 100	Two-hybrid	BioGRID	16189514
CCDC33	FLJ23168 \| FLJ32855 \| MGC34145	coiled-coil domain containing 33	Two-hybrid	BioGRID	16189514
CSNK1E	HCKIE \| MGC10398	casein kinase 1, epsilon	Two-hybrid	BioGRID	16189514
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Affinity Capture-Western	BioGRID	10806215
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	10806215
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	12805222
DDI1	FLJ36017	DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)	Two-hybrid	BioGRID	16189514
DPPA2	PESCRG1	developmental pluripotency associated 2	Two-hybrid	BioGRID	16189514
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	Affinity Capture-Western Two-hybrid	BioGRID	16189514
FAM105B	FLJ34884	family with sequence similarity 105, member B	Two-hybrid	BioGRID	16189514
FLJ12529	FLJ39024 \| MGC9315	pre-mRNA cleavage factor I, 59 kDa subunit	Two-hybrid	BioGRID	16189514
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-Western	BioGRID	10829020
MCRS1	ICP22BP \| INO80Q \| MCRS2 \| MSP58 \| P78	microspherule protein 1	Two-hybrid	BioGRID	16189514
PCBD1	DCOH \| PCBD \| PCD \| PHS	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	Two-hybrid	BioGRID	16189514
POLI	RAD30B \| RAD3OB	polymerase (DNA directed) iota	Two-hybrid	BioGRID	16189514
PRPF3	HPRP3 \| HPRP3P \| PRP3 \| Prp3p \| RP18	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
RHOXF2	PEPP-2 \| PEPP2 \| THG1	Rhox homeobox family, member 2	Two-hybrid	BioGRID	16189514
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Two-hybrid	BioGRID	16189514
SNF8	Dot3 \| EAP30 \| VPS22	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
SNIP1	FLJ12553 \| RP3-423B22.3 \| dJ423B22.2	Smad nuclear interacting protein 1	Two-hybrid	BioGRID	16189514
SORBS3	SCAM-1 \| SCAM1 \| SH3D4 \| VINEXIN	sorbin and SH3 domain containing 3	Two-hybrid	BioGRID	16189514
TCEB3B	ELOA2 \| HsT832 \| MGC119351 \| TCEB3L	transcription elongation factor B polypeptide 3B (elongin A2)	Two-hybrid	BioGRID	16189514
THAP1	FLJ10477 \| MGC33014	THAP domain containing, apoptosis associated protein 1	Two-hybrid	BioGRID	16189514
TIFA	MGC20791 \| T2BP \| T6BP \| TIFAA	TRAF-interacting protein with forkhead-associated domain	Two-hybrid	BioGRID	16189514
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16189514
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
U2AF2	U2AF65	U2 small nuclear RNA auxiliary factor 2	Two-hybrid	BioGRID	16189514
USP5	ISOT	ubiquitin specific peptidase 5 (isopeptidase T)	Two-hybrid	BioGRID	16189514
VANGL1	LPP2 \| MGC5338 \| STB2 \| STBM2	vang-like 1 (van gogh, Drosophila)	-	HPRD	15456783
ZBTB8	BOZF1 \| FLJ90065 \| MGC17919	zinc finger and BTB domain containing 8	Two-hybrid	BioGRID	16189514
ZNF165	LD65 \| ZSCAN7	zinc finger protein 165	Affinity Capture-Western Two-hybrid	BioGRID	16189514
ZNF250	FLJ57354 \| MGC111123 \| MGC9718 \| ZFP647 \| ZNF647	zinc finger protein 250	Two-hybrid	BioGRID	16189514
ZNF263	FPM315 \| ZKSCAN12	zinc finger protein 263	Two-hybrid	BioGRID	16189514

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
KEGG_NOTCH_SIGNALING_PATHWAY	47	35	All SZGR genes in this pathway
KEGG_MELANOGENESIS	102	80	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA	55	44	All SZGR genes in this pathway
WNT_SIGNALING	89	71	All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY	32	26	All SZGR genes in this pathway
PID_BETA_CATENIN_DEG_PATHWAY	18	17	All SZGR genes in this pathway
PID_WNT_CANONICAL_PATHWAY	20	18	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_HIPPO	22	15	All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN	663	425	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN	36	24	All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_1	13	11	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR	37	22	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4	307	185	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	138	92	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP	221	150	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP	430	288	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	126	133	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	126	133	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-138	138	145	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-27	127	133	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	127	133	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-495	460	466	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.