Gene Page: EDA

Summary
GeneID  1896
Symbol  EDA
Synonyms  ED1|ED1-A1|ED1-A2|EDA1|EDA2|HED|XHED|XLHED
Description  ectodysplasin A
See related  HGNC:3157|MIM:300451|Ensembl:ENSG00000158813|HPRD:02347|
Locus tag  RP11-351K23.1
Gene type  protein-coding
Map location  Xq12-q13.1|Xq12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LAMA40.760.73
ETS10.730.78
LAMC10.710.70
FN10.710.71
VCL0.690.70
PCDH180.690.70
FLVCR20.690.59
NID10.690.64
ELK30.680.72
OLFML30.680.63
Top 10 negatively co-expressed genes
FXYD1-0.39-0.36
AF347015.21-0.39-0.38
MT-CO2-0.37-0.40
S100A13-0.36-0.34
MT1G-0.36-0.34
AC098691.2-0.35-0.36
APOC1-0.34-0.30
AF347015.31-0.34-0.37
CA5A-0.34-0.32
AF347015.8-0.34-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)11039935 
GO:0005164tumor necrosis factor receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001942hair follicle developmentIEA-
GO:0007160cell-matrix adhesionIEA-
GO:0007398ectoderm developmentTAS8696334 
GO:0007165signal transductionTAS8696334 
GO:0007431salivary gland developmentIEA-
GO:0006955immune responseIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0042346positive regulation of NF-kappaB import into nucleusIEA-
GO:0030154cell differentiationIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA11039935 
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0043473pigmentationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonTAS10484778 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005576extracellular regionIEA-
GO:0005624membrane fractionTAS8696334 
GO:0005886plasma membraneTAS9736768 |10484778 
GO:0005887integral to plasma membraneIEA-
GO:0045177apical part of cellIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EDA2REDA-A2R | EDAA2R | TNFRSF27 | XEDARectodysplasin A2 receptor-HPRD,BioGRID11039935 |12270937 
EDARDL | ED1R | ED3 | ED5 | EDA-A1R | EDA1R | EDA3 | FLJ94390ectodysplasin A receptor-HPRD,BioGRID11309369 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ODONNELL_METASTASIS_UP 8258All SZGR genes in this pathway
WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT 6637All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98845851m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-130/3013133201A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1494652m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/4977278m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1504248m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-22627633m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-24303930461A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-324-5p314231481Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-342374837551A,m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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