Gene Page: PHC1

Summary
GeneID  1911
Symbol  PHC1
Synonyms  EDR1|HPH1|RAE28
Description  polyhomeotic homolog 1 (Drosophila)
See related  HGNC:3182|MIM:602978|Ensembl:ENSG00000111752|HPRD:16009|
Locus tag  -
Gene type  protein-coding
Map location  12p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingTAS9121482 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusTAS9121482 
GO:0005730nucleolusIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMI1MGC12685 | PCGF4 | RNF51BMI1 polycomb ring finger oncogeneHPH1 interacts with Bmi1.BIND15563468 
-HPRD,BioGRID9121482 
-HPRD9009205 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)HPH1 interacts with HPc2.BIND15563468 
Affinity Capture-WesternBioGRID9199346 
GMNNGem | RP3-369A17.3geminin, DNA replication inhibitor-HPRD14973489 
PHC2EDR2 | HPH2 | MGC163502 | PH2polyhomeotic homolog 2 (Drosophila)-HPRD,BioGRID9121482 
RING1RING1A | RNF1ring finger protein 1Affinity Capture-WesternBioGRID9199346 
RNF2BAP-1 | BAP1 | DING | HIPI3 | RING1B | RING2ring finger protein 2-HPRD12183370 
SCMH1Scml3sex comb on midleg homolog 1 (Drosophila)-HPRD10653359 
SFMBT1DKFZp434L243 | RU1 | SFMBTScm-like with four mbt domains 1Two-hybridBioGRID16189514 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KORKOLA_EMBRYONAL_CARCINOMA_UP 4127All SZGR genes in this pathway
KORKOLA_SEMINOMA_UP 4427All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_CIS 76All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER 5030All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
CONRAD_STEM_CELL 3927All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
MIKKELSEN_DEDIFFERENTIATED_STATE_UP 85All SZGR genes in this pathway
KORKOLA_CORRELATED_WITH_POU5F1 3412All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14913181324m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-24131613231A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-291621691A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-45299610031A,m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-493-5p9379431Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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