Gene Page: ELA2

Summary
GeneID  1991
Symbol  ELA2
Synonyms  GE|HLE|HNE|NE|PMN-E
Description  elastase 2, neutrophil
See related  HGNC:3309|MIM:130130|Ensembl:ENSG00000197561|HPRD:00554|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HTRA30.730.65
MMP20.710.76
VCAM10.690.71
CTHRC10.690.49
PROCR0.690.55
HAPLN30.680.67
LAMA40.680.75
STRA60.680.61
COL6A20.670.83
FLVCR20.660.64
Top 10 negatively co-expressed genes
EVI2A-0.29-0.31
SEPT4-0.28-0.27
ASPA-0.28-0.24
CRYAB-0.28-0.22
MAL-0.27-0.25
AF347015.27-0.27-0.26
SFTPC-0.27-0.25
C13orf16-0.27-0.28
S100A1-0.27-0.19
AP000907.5-0.27-0.21
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0008367bacterial bindingNAS14705961 
GO:0019955cytokine bindingIPI12393522 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0009411response to UVIDA11928814 
GO:0006909phagocytosisIEA-
GO:0006874cellular calcium ion homeostasisNAS15140022 
GO:0050922negative regulation of chemotaxisNAS15140022 
GO:0030163protein catabolic processNAS12887060 
GO:0043406positive regulation of MAP kinase activityNAS14730209 
GO:0050728negative regulation of inflammatory responseNAS15140022 
GO:0045079negative regulation of chemokine biosynthetic processIDA12223522 
GO:0048661positive regulation of smooth muscle cell proliferationIDA15010259 
GO:0045415negative regulation of interleukin-8 biosynthetic processIDA12223522 
GO:0045416positive regulation of interleukin-8 biosynthetic processIDA14730209 
GO:0050900leukocyte migrationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS12114510 
GO:0009986cell surfaceIDA12114510 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ELA2GE | HLE | HNE | NE | PMN-Eelastase 2, neutrophil-HPRD12190311 
ELNFLJ38671 | FLJ43523 | SVAS | WBS | WSelastin-HPRD10471600 
KNG1BDK | KNGkininogen 1-HPRD,BioGRID12887060 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)LRP interacts with Elastase 2.BIND15131125 
NOTCH2NLN2NNotch homolog 2 (Drosophila) N-terminal like-HPRD,BioGRID14673143 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1-HPRD9565572 
SERPINA1A1A | A1AT | AAT | MGC23330 | MGC9222 | PI | PI1 | PRO2275serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Reconstituted ComplexBioGRID10867014 
Alpha-1 PI interacts with and inhibits neutrophil elastase.BIND15131125 
SERPINA3AACT | ACT | GIG24 | GIG25 | MGC88254serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3-HPRD,BioGRID8011628 |8718849 
SERPINB1EI | ELANH2 | LEI | M/NEI | MNEI | PI2serpin peptidase inhibitor, clade B (ovalbumin), member 1Biochemical Activity
in vitro		BioGRID10924364 
SERPINB13HSHUR7SEQ | HUR7 | MGC126870 | PI13 | headpinserpin peptidase inhibitor, clade B (ovalbumin), member 13-HPRD10512713 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1-HPRD7521069 
SERPINF2A2AP | AAP | ALPHA-2-PI | API | PLIserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2-HPRD,BioGRID2437112 |6980881 
SERPING1C1IN | C1INH | C1NH | HAE1 | HAE2serpin peptidase inhibitor, clade G (C1 inhibitor), member 1-HPRD,BioGRID6980881 
SLPIALK1 | ALP | BLPI | HUSI | HUSI-I | MPI | WAP4 | WFDC4secretory leukocyte peptidase inhibitor-HPRD10702419 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID8463250 
 


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