Gene Page: A2M

Summary
GeneID  2
Symbol  A2M
Synonyms  CPAMD5|DKFZp779B086|FWP007|S863-7
Description  alpha-2-macroglobulin
See related  HGNC:7|MIM:103950|HPRD:00072|
Locus tag  -
Gene type  protein-coding
Map location  12p13.3-p12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 4.179 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NDUFB70.880.47
LSMD10.870.51
C17orf900.850.61
ZNF5930.840.58
C7orf590.830.58
C19orf600.830.70
HBQ10.830.62
C9orf160.830.55
PSMB100.820.50
NDUFA20.820.49
Top 10 negatively co-expressed genes
CANX-0.39-0.37
AC005332.1-0.38-0.30
ARHGAP5-0.38-0.40
DYNC1LI2-0.37-0.30
ZNHIT6-0.37-0.34
KIAA1033-0.37-0.37
RAB5A-0.37-0.32
XPOT-0.36-0.29
CD2AP-0.36-0.36
YES1-0.36-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0017114wide-spectrum protease inhibitor activityIEA-
GO:0019959interleukin-8 bindingIPI10880251 
GO:0019966interleukin-1 bindingIDA9714181 
GO:0019899enzyme bindingIPI11435418 
GO:0043120tumor necrosis factor bindingIDA9714181 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051260protein homooligomerizationNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP59727 
GO:0005576extracellular regionNAS14718574 
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0031093platelet alpha granule lumenEXP59727 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAM19FKSG34 | MADDAM | MLTNBADAM metallopeptidase domain 19 (meltrin beta)-HPRD11162584 
ADAMTS1C3-C5 | KIAA1346 | METH1ADAM metallopeptidase with thrombospondin type 1 motif, 1-HPRD,BioGRID10373500 
AMBPEDC1 | HCP | HI30 | IATIL | ITI | ITIL | ITILC | UTIalpha-1-microglobulin/bikunin precursor-HPRD,BioGRID1697852 |7519849 
|7533162 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD,BioGRID9831625 
B2M-beta-2-microglobulin-HPRD,BioGRID10731476 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)Reconstituted ComplexBioGRID8662763 
CTSBAPPS | CPSBcathepsin B-HPRD2476070 
ELA1-elastase 1, pancreatic-HPRD6153632 |6191979 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID12194978 
IL10CSIF | IL-10 | IL10A | MGC126450 | MGC126451 | TGIFinterleukin 10-HPRD,BioGRID10714547 
IL1BIL-1 | IL1-BETA | IL1F2interleukin 1, beta-HPRD9714181 
IL4BCGF-1 | BCGF1 | BSF1 | IL-4 | MGC79402interleukin 4Reconstituted ComplexBioGRID10714547 
KLK13DKFZp586J1923 | KLK-L4 | KLKL4kallikrein-related peptidase 13Reconstituted ComplexBioGRID14687906 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3-HPRD8583572 
Affinity Capture-WesternBioGRID1702714 
LCAT-lecithin-cholesterol acyltransferase-HPRD,BioGRID11435418 
LEPFLJ94114 | OB | OBSleptin-HPRD,BioGRID9724081 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID10652313 
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Reconstituted ComplexBioGRID9344465 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)-HPRD,BioGRID10681572 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial protein-HPRD,BioGRID11023837 
PDGFBFLJ12858 | PDGF2 | SIS | SSV | c-sisplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)-HPRD10681572 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)An unspecified isoform of STAT3 binds APRE.BIND15950906 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 1512All SZGR genes in this pathway
REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE 3222All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY 1712All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
KORKOLA_TERATOMA_UP 1611All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_UP 3320All SZGR genes in this pathway
HU_ANGIOGENESIS_DN 3725All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN 2518All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_DN 1913All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX1_UP 1510All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_CIS 76All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
COLLER_MYC_TARGETS_DN 95All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_DN 3021All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP 7848All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
ABE_VEGFA_TARGETS 2015All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
TSAI_RESPONSE_TO_RADIATION_THERAPY 3220All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
ISSAEVA_MLL2_TARGETS 6235All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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