Gene Page: ELK1

Summary
GeneID  2002
Symbol  ELK1
Synonyms  -
Description  ELK1, member of ETS oncogene family
See related  HGNC:3321|MIM:311040|Ensembl:ENSG00000126767|HPRD:02407|
Locus tag  -
Gene type  protein-coding
Map location  Xp11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.879 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SMG50.870.88
FLII0.850.86
GRIPAP10.850.85
RECQL50.840.85
XPC0.840.85
FAM160B20.840.86
MYBBP1A0.840.85
FKBP150.840.84
DDX270.830.85
POLG0.830.84
Top 10 negatively co-expressed genes
AF347015.21-0.70-0.68
AF347015.31-0.65-0.60
C1orf54-0.64-0.62
CLEC2B-0.61-0.62
MT-CO2-0.60-0.56
GNG11-0.59-0.59
AF347015.27-0.58-0.56
IFI27-0.58-0.53
VAMP5-0.58-0.57
HIGD1B-0.58-0.54
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA14970218 
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIPI16291755 |16533805 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA14970218 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIC14970218 
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD11313879 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD1547942 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-Western
Phenotypic Enhancement
Reconstituted Complex		BioGRID12514134 
EWSR1EWSEwing sarcoma breakpoint region 1Reconstituted ComplexBioGRID9010223 
FLI1EWSR2 | SIC-1Friend leukemia virus integration 1Reconstituted ComplexBioGRID9010223 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD7540136 
FOSL1FRA | FRA1 | fra-1FOS-like antigen 1Elk1 interacts with the region of the FRA-1 promoter containing the SRE and ATF sites.BIND15806162 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD8798570 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD8798570 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Mapk1 (p42Mapk) phosphorylates Elk1 at Ser383.BIND15782123 
-HPRD8208531 |8586671 
Biochemical Activity
Reconstituted Complex		BioGRID8586671 |12594221 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11p38-2 interacts with and phosphorylates Elk1.BIND9235954 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14Elk-1 is phosphorylated by an unspecified isoform of p38 MAPK. This interaction was modeled on a demonstrated interaction between human Elk-1 and p38 MAPK from an unspecified species.BIND9130707 
-HPRD8622669 
An unspecified isoform of p38 interacts with and phosphorylates Elk-1.BIND9155018 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.BIND9130707 
-HPRD8208531 |12473660 
Mapk3 (p44Mapk) phosphorylates Elk1 at Ser383.BIND15782123 
ERK1 interacts with and phosphorylates Elk1. This interaction was modelled on a demonstrated interaction between rat ERK1 and human Elk1.BIND9235954 
Elk-1 is phosphorylated by ERK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and ERK-1 from an unspecified species.BIND9020136 
ERK1 interacts with and phosphorylates Elk-1.BIND9155018 
Erk1 phosphorylates Elk-1. This interaction was modeled on a demonstrated interaction between Erk1 and Elk-1 from an unspecified species.BIND10431817 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8An unspecified isoform of JNK1 interacts with and phosphorylates Elk1.BIND9235954 
Biochemical ActivityBioGRID8586671 
Elk-1 is phosphorylated by JNK-1. This interaction was modeled on a demonstrated interaction between human Elk-1 and JNK-1 from an unspecified species.BIND9020136 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9An unspecified isoform of JNK2 interacts with and phosphorylates Elk-1.BIND9155018 
PIAS2MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | mizprotein inhibitor of activated STAT, 2ELK1 interacts with PIAS2a (PIASX-alpha).BIND15920481 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD11279280 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD,BioGRID9010223 
STK16FLJ39635 | KRCT | MPSK | PKL12 | TSF1serine/threonine kinase 16-HPRD,BioGRID10947953 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY 1913All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY 1813All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_TOLL_PATHWAY 3731All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
SA_TRKA_RECEPTOR 1715All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY 1414All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_PDGFRA_PATHWAY 2218All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
LIU_PROSTATE_CANCER_UP 9657All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
TURJANSKI_MAPK1_AND_MAPK2_TARGETS 1210All SZGR genes in this pathway
TURJANSKI_MAPK8_AND_MAPK9_TARGETS 87All SZGR genes in this pathway
TURJANSKI_MAPK11_TARGETS 55All SZGR genes in this pathway
TURJANSKI_MAPK14_TARGETS 1010All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4 1812All SZGR genes in this pathway
GRADE_COLON_CANCER_DN 3322All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_UP 107All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-135678684m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-136729735m8hsa-miR-136ACUCCAUUUGUUUUGAUGAUGGA
miR-150541547m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-18549561A,m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-219365371m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-326125112581A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-382191197m8hsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG
miR-5394054121A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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