Gene Page: EN1

Summary
GeneID  2019
Symbol  EN1
Synonyms  -
Description  engrailed homeobox 1
See related  HGNC:3342|MIM:131290|Ensembl:ENSG00000163064|HPRD:08835|
Locus tag  -
Gene type  protein-coding
Map location  2q13-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ABCB10.870.88
TPCN10.860.89
KANK10.860.87
ATP1A20.860.87
SFXN50.860.84
GPR37L10.850.83
SEMA3G0.850.85
NACC20.850.91
SLC6A120.850.90
PRELP0.840.90
Top 10 negatively co-expressed genes
POLB-0.67-0.77
MED19-0.67-0.72
FRG1-0.66-0.79
TRNAU1AP-0.66-0.73
OCIAD2-0.66-0.73
ING4-0.65-0.70
DUSP12-0.65-0.68
ALKBH2-0.65-0.75
COMMD3-0.65-0.76
NR2C2AP-0.64-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005249voltage-gated potassium channel activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048666neuron developmentIEAneuron (GO term level: 9)-
GO:0030917midbrain-hindbrain boundary developmentIEABrain (GO term level: 10)-
GO:0030902hindbrain developmentIEABrain (GO term level: 8)-
GO:0030901midbrain developmentIEABrain (GO term level: 8)-
GO:0001501skeletal system developmentTAS8684466 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009954proximal/distal pattern formationIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0009653anatomical structure morphogenesisTAS8094370 
GO:0006813potassium ion transportIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0043473pigmentationIEA-
GO:0035115embryonic forelimb morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0008076voltage-gated potassium channel complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PAX6AN | AN2 | D11S812E | MGC17209 | MGDA | WAGRpaired box 6Reconstituted ComplexBioGRID11069920 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DOANE_BREAST_CANCER_ESR1_DN 4828All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_UP 3920All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
BOUDOUKHA_BOUND_BY_IGF2BP2 11159All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128754760m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-181478484m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-292002061Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-3383503561Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p3944001Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3744034101A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4916716771Ahsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
miR-97067121Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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