Gene Page: EPB42

Summary
GeneID  2038
Symbol  EPB42
Synonyms  MGC116735|MGC116737|PA
Description  erythrocyte membrane protein band 4.2
See related  HGNC:3381|MIM:177070|Ensembl:ENSG00000166947|HPRD:01517|
Locus tag  -
Gene type  protein-coding
Map location  15q15-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0494 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C9orf610.790.84
PIPOX0.780.83
BDH20.780.85
ANKRD350.780.79
HADHB0.770.84
NPL20.760.83
A2ML10.760.76
ADHFE10.760.84
PBXIP10.750.84
FAH0.750.85
Top 10 negatively co-expressed genes
NOL4-0.54-0.65
DPF1-0.53-0.64
ARL4D-0.52-0.61
MYT1L-0.52-0.64
PRKAR2B-0.52-0.64
GPRIN1-0.52-0.62
MEF2C-0.52-0.67
PPAPR5-0.51-0.65
CECR6-0.51-0.60
PLK2-0.51-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003810protein-glutamine gamma-glutamyltransferase activityIEA-
GO:0005515protein bindingIPI12970870 
GO:0005524ATP bindingTAS8608138 
GO:0005200structural constituent of cytoskeletonTAS1350227 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008360regulation of cell shapeIEA-
GO:0018149peptide cross-linkingIEA-
GO:0043249erythrocyte maturationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonTAS1350227 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS1350227 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANK2DKFZp686M09125 | DKFZp686P0948 | FLJ38277 | LQT4ankyrin 2, neuronalReconstituted ComplexBioGRID2968981 
CD47IAP | MER6 | OA3CD47 molecule-HPRD12176912 
CNOBCAS4L | FLJ11230cappuccino homolog (mouse)-HPRD12576321 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD2968981 
EPB49DMT | FLJ78462 | FLJ98848erythrocyte membrane protein band 4.9 (dematin)-HPRD8608138 
KRASC-K-RAS | K-RAS2A | K-RAS2B | K-RAS4A | K-RAS4B | KI-RAS | KRAS1 | KRAS2 | NS3 | RASK2v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologReconstituted ComplexBioGRID3276554 
SLC4A1AE1 | BND3 | CD233 | DI | EMPB3 | EPB3 | FR | MGC116750 | MGC116753 | MGC126619 | MGC126623 | RTA1A | SW | WD | WD1 | WRsolute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)Protein-peptideBioGRID7626035 
SPINK7ECG2 | ECRG2 | MGC133105 | MGC133106serine peptidase inhibitor, Kazal type 7 (putative)-HPRD,BioGRID12970870 
ECRG2 interacts with EPB42.BIND12970870 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD,BioGRID12049649 
STX12MGC51957 | STX13 | STX14syntaxin 12-HPRD11936273 
-HPRD10610180 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
SWEET_KRAS_TARGETS_DN 6639All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
STEINER_ERYTHROCYTE_MEMBRANE_GENES 1510All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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