Gene Page: EPHA3

Summary
GeneID  2042
Symbol  EPHA3
Synonyms  ETK|ETK1|HEK|HEK4|TYRO4
Description  EPH receptor A3
See related  HGNC:3387|MIM:179611|Ensembl:ENSG00000044524|HPRD:01555|
Locus tag  -
Gene type  protein-coding
Map location  3p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.04047 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DGAT10.770.72
FBXO170.750.75
TMEM161A0.750.78
LRRC4B0.750.73
RNF1260.740.75
TMEM1800.740.72
CHST120.740.72
AGPAT10.740.73
VAC140.740.71
SCAP0.730.71
Top 10 negatively co-expressed genes
AF347015.21-0.55-0.52
AL139819.3-0.53-0.55
AF347015.8-0.51-0.47
AF347015.31-0.50-0.46
AF347015.27-0.49-0.48
MT-ATP8-0.49-0.49
MT-CO2-0.49-0.45
MT-CYB-0.48-0.44
NOSTRIN-0.47-0.42
AF347015.18-0.46-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005003ephrin receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS1737782 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1737782 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID11870224 
EFNA1B61 | ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4ephrin-A1Reconstituted ComplexBioGRID9195962 
EFNA2ELF-1 | EPLG6 | HEK7-L | LERK6ephrin-A2-HPRD9751130 
EFNA3EFL2 | EPLG3 | Ehk1-L | LERK3ephrin-A3Reconstituted ComplexBioGRID9195962 
EFNA4EFL4 | EPLG4 | LERK4 | MGC125826ephrin-A4Reconstituted ComplexBioGRID9195962 
EFNA5AF1 | EFL5 | EPLG7 | GLC1M | LERK7 | RAGSephrin-A5-HPRD,BioGRID9195962 
-HPRD9195962|9751130 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1Reconstituted ComplexBioGRID9195962 
EFNB2EPLG5 | HTKL | Htk-L | LERK5 | MGC126226 | MGC126227 | MGC126228ephrin-B2-HPRD,BioGRID8559144 
RUFY1FLJ22251 | RABIP4 | ZFYVE12RUN and FYVE domain containing 1-HPRD11877430 
RUFY2FLJ10063 | KIAA1537 | RABIP4R | ZFYVE13RUN and FYVE domain containing 2-HPRD11877430 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Reconstituted ComplexBioGRID15355990 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_UP 2820All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PLASARI_NFIC_TARGETS_BASAL_DN 1813All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/984604661Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-124.11351421A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061351411Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-13524522458m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1827127181Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1946997051Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-29976982m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-325227222781Ahsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-381930936m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-487b22452251m8hsa-miR-487bAAUCGUACAGGGUCAUCCACUU
miR-488470476m8hsa-miR-488CCCAGAUAAUGGCACUCUCAA
miR-4956977031Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496255825641Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
miR-7129613031A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-967117181A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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