Gene Page: EPS8

Summary
GeneID  2059
Symbol  EPS8
Synonyms  -
Description  epidermal growth factor receptor pathway substrate 8
See related  HGNC:3420|MIM:600206|Ensembl:ENSG00000151491|HPRD:02563|
Locus tag  -
Gene type  protein-coding
Map location  12q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.5193 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C9orf1020.920.93
OSBP0.920.92
ZBTB430.910.93
DDX3X0.910.92
UTP14C0.910.92
USP70.910.91
GIGYF20.900.92
ANKRD280.900.91
THUMPD10.900.92
SNX270.900.91
Top 10 negatively co-expressed genes
AF347015.31-0.73-0.76
AF347015.21-0.73-0.77
FXYD1-0.72-0.74
HIGD1B-0.72-0.76
MT-CO2-0.71-0.75
ENHO-0.70-0.77
C1orf54-0.70-0.79
IFI27-0.69-0.73
CST3-0.68-0.73
TLCD1-0.68-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS8084614 
GO:0005515protein bindingIPI9010225 |15289329 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007173epidermal growth factor receptor signaling pathwayTAS8084614 
GO:0007165signal transductionTAS8084614 
GO:0008283cell proliferationTAS8084614 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1-HPRD1049958 |9010225 
|11099046 |12127568 
Affinity Capture-Western
Reconstituted Complex		BioGRID9010225 |11099046 
|14565974 
BAIAP2BAP2 | IRSP53BAI1-associated protein 2-HPRD,BioGRID15289329 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
DNALI1P28 | dJ423B22.5 | hp28dynein, axonemal, light intermediate chain 1Two-hybridBioGRID16169070 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)-HPRD,BioGRID10581192 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD7532293 |12127568 
EPS8-epidermal growth factor receptor pathway substrate 8Affinity Capture-Western
Co-crystal Structure
Two-hybrid		BioGRID9303002 |16189514 
HOOK2FLJ26218 | HK2hook homolog 2 (Drosophila)Two-hybridBioGRID16189514 
JTV1AIMP2 | P38 | PRO0992JTV1 geneTwo-hybridBioGRID16189514 
MRPL20L20mt | MGC4779 | MGC74465 | MRP-L20mitochondrial ribosomal protein L20Two-hybridBioGRID16169070 
MYO15ADFNB3 | DKFZp686N18198 | FLJ17274 | FLJ31311 | MYO15myosin XVATwo-hybridBioGRID16169070 
PCM1PTC4pericentriolar material 1Two-hybridBioGRID16189514 
PLDNPA | PALLIDpallidin homolog (mouse)Two-hybridBioGRID16189514 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein BShb interacts with Eps8. This interaction was modelled on a demonstrated interaction between human Shb and murine Eps8BIND7537362 
-HPRD,BioGRID7537362 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID7791787 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-WesternBioGRID10499589 |14565974 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10395945 
TEX28CXorf2 | fTEXtestis expressed 28Two-hybridBioGRID16189514 
USP6NLKIAA0019 | RNTRE | TRE2NLUSP6 N-terminal like-HPRD,BioGRID8700515 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50610951101m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-200bc/429773779m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/21171771Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-25/32/92/363/367112711331Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-381103810441Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-54310331039m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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