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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: EWSR1

Summary

GeneID

2130

Symbol

EWSR1

Synonyms

EWS

Description

Ewing sarcoma breakpoint region 1

Locus tag

AC002059.7

Gene type

protein-coding

Map location

22q12.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.017

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

CUL9

0.87

0.88

ZCCHC2

0.86

0.89

IPPK

0.86

EIF4G3

0.86

VPS53

0.86

STAT2

0.85

0.86

PDCD6IP

0.85

UBE3B

0.85

ZNF331

0.85

0.84

MAP3K4

0.85

Top 10 negatively co-expressed genes

AF347015.21

-0.72

-0.64

AF347015.31

-0.65

-0.58

C1orf54

-0.65

-0.67

GNG11

-0.65

-0.62

HIGD1B

-0.64

-0.58

MT-CO2

-0.63

-0.56

VAMP5

-0.63

-0.61

IL32

-0.63

-0.57

PLA2G5

-0.61

-0.57

METRN

-0.61

-0.58

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003676

nucleic acid binding

IEA

GO:0003700

transcription factor activity

IEA

GO:0003723

RNA binding

TAS

8084618

GO:0005516

calmodulin binding

IEA

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

GO:0043565

sequence-specific DNA binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IEA

GO:0009986

cell surface

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTL6A	ACTL6 \| Arp4 \| BAF53A \| INO80K \| MGC5382	actin-like 6A	Two-hybrid	BioGRID	16189514
AGT	ANHU \| FLJ92595 \| FLJ97926 \| SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Two-hybrid	BioGRID	16189514
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Affinity Capture-MS	BioGRID	17353931
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	Two-hybrid	BioGRID	16189514
BARD1	-	BRCA1 associated RING domain 1	-	HPRD,BioGRID	12183411
BNIP3L	BNIP3a \| NIX	BCL2/adenovirus E1B 19kDa interacting protein 3-like	Two-hybrid	BioGRID	16189514
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD,BioGRID	9201297
C10orf12	DKFZp564P1916 \| FLJ13022	chromosome 10 open reading frame 12	Two-hybrid	BioGRID	16189514
C11orf16	-	chromosome 11 open reading frame 16	Two-hybrid	BioGRID	16189514
C18orf10	DKFZp586M1523 \| HMFN0601 \| HsT3006 \| L17 \| PGs2	chromosome 18 open reading frame 10	Two-hybrid	BioGRID	16189514
C19orf50	FLJ25480 \| MGC2749 \| MST096 \| MSTP096	chromosome 19 open reading frame 50	Two-hybrid	BioGRID	16189514
C19orf57	MGC11271 \| MGC149720	chromosome 19 open reading frame 57	Two-hybrid	BioGRID	16189514
C1orf71	FLJ32001 \| MGC18089	chromosome 1 open reading frame 71	Two-hybrid	BioGRID	16189514
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	Reconstituted Complex	BioGRID	9341188
CCDC7	BioT2-A \| BioT2-B \| BioT2-C \| DKFZp686N0559 \| FLJ32762 \| RP11-479G22.1	coiled-coil domain containing 7	Two-hybrid	BioGRID	16189514
CCDC91	DKFZp779L1558 \| FLJ11088 \| HSD8 \| p56	coiled-coil domain containing 91	Two-hybrid	BioGRID	16189514
CD177	HNA2A \| NB1 \| PRV1	CD177 molecule	Two-hybrid	BioGRID	16189514
CD2BP2	FWP010 \| LIN1 \| Snu40 \| U5-52K	CD2 (cytoplasmic tail) binding protein 2	Affinity Capture-MS	BioGRID	17353931
CEACAM5	CD66e \| CEA \| DKFZp781M2392	carcinoembryonic antigen-related cell adhesion molecule 5	Two-hybrid	BioGRID	16189514
CETP	HDLCQ10	cholesteryl ester transfer protein, plasma	Two-hybrid	BioGRID	16189514
CFDP1	BCNT \| BUCENTAUR \| CP27 \| SWC5 \| Yeti \| p97	craniofacial development protein 1	Two-hybrid	BioGRID	16189514
CPSF6	CFIM \| CFIM68 \| HPBRII-4 \| HPBRII-7	cleavage and polyadenylation specific factor 6, 68kDa	Two-hybrid	BioGRID	16189514
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	12459554
CUEDC2	C10orf66 \| MGC2491 \| bA18I14.5	CUE domain containing 2	Two-hybrid	BioGRID	16189514
CXADR	CAR \| HCAR	coxsackie virus and adenovirus receptor	Two-hybrid	BioGRID	16189514
DFFA	DFF-45 \| DFF1 \| ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	Two-hybrid	BioGRID	16189514
DMRTB1	-	DMRT-like family B with proline-rich C-terminal, 1	Two-hybrid	BioGRID	16189514
DNAJB3	HCG3 \| MGC26879	DnaJ (Hsp40) homolog, subfamily B, member 3	Two-hybrid	BioGRID	16189514
DYNLL2	DNCL1B \| Dlc2 \| MGC17810	dynein, light chain, LC8-type 2	Two-hybrid	BioGRID	16189514
ELAVL3	DKFZp547J036 \| HUC \| HUCL \| MGC20653 \| PLE21	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	Two-hybrid	BioGRID	16189514
ELAVL4	HUD \| PNEM	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	Two-hybrid	BioGRID	16189514
ELK1	-	ELK1, member of ETS oncogene family	Reconstituted Complex	BioGRID	9010223
FAM131C	C1orf117 \| FLJ36766 \| RP11-5P18.9	family with sequence similarity 131, member C	Two-hybrid	BioGRID	16189514
FASN	FAS \| MGC14367 \| MGC15706 \| OA-519	fatty acid synthase	Two-hybrid	BioGRID	16189514
FLJ12529	FLJ39024 \| MGC9315	pre-mRNA cleavage factor I, 59 kDa subunit	Two-hybrid	BioGRID	16189514
GNPDA1	GNPDA \| GNPI \| GPI \| HLN \| KIAA0060	glucosamine-6-phosphate deaminase 1	Two-hybrid	BioGRID	16189514
GPBP1L1	RP11-767N6.1 \| SP192	GC-rich promoter binding protein 1-like 1	Two-hybrid	BioGRID	16189514
GSK3B	-	glycogen synthase kinase 3 beta	Affinity Capture-MS	BioGRID	17353931
HERPUD1	HERP \| KIAA0025 \| Mif1 \| SUP	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	Two-hybrid	BioGRID	16189514
HMGA1	HMG-R \| HMGA1A \| HMGIY \| MGC12816 \| MGC4242 \| MGC4854	high mobility group AT-hook 1	Two-hybrid	BioGRID	16189514
ILK	DKFZp686F1765 \| P59	integrin-linked kinase	Affinity Capture-MS	BioGRID	17353931
KCNMB1	K(VCA)beta \| SLO-BETA \| hslo-beta	potassium large conductance calcium-activated channel, subfamily M, beta member 1	Two-hybrid	BioGRID	16189514
KEL	CD238 \| ECE3	Kell blood group, metallo-endopeptidase	Two-hybrid	BioGRID	16189514
KHDRBS2	FLJ38664 \| MGC26664 \| SLM-1 \| SLM1 \| bA535F17.1	KH domain containing, RNA binding, signal transduction associated 2	Two-hybrid	BioGRID	16189514
KRR1	HRB2 \| RIP-1	KRR1, small subunit (SSU) processome component, homolog (yeast)	Two-hybrid	BioGRID	16189514
LILRA3	CD85E \| HM31 \| HM43 \| ILT6 \| LIR-4 \| LIR4 \| e3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	Two-hybrid	BioGRID	16189514
MAGEA11	MAGE-11 \| MAGE11 \| MAGEA-11 \| MGC10511	melanoma antigen family A, 11	Two-hybrid	BioGRID	16189514
MAPK1IP1L	C14orf32 \| MGC23138 \| MISS \| c14_5346	mitogen-activated protein kinase 1 interacting protein 1-like	Two-hybrid	BioGRID	16189514
MATK	CHK \| CTK \| DKFZp434N1212 \| HHYLTK \| HYL \| HYLTK \| Lsk \| MGC1708 \| MGC2101	megakaryocyte-associated tyrosine kinase	Two-hybrid	BioGRID	16189514
MDFI	I-MF \| I-mfa	MyoD family inhibitor	Two-hybrid	BioGRID	16189514
MNS1	FLJ11222 \| FLJ26051	meiosis-specific nuclear structural 1	Two-hybrid	BioGRID	16189514
MRPS18B	C6orf14 \| DKFZp564H0223 \| HSPC183 \| HumanS18a \| MRP-S18-2 \| MRPS18-2 \| PTD017 \| S18amt	mitochondrial ribosomal protein S18B	Two-hybrid	BioGRID	16189514
MSC	ABF-1 \| ABF1 \| MYOR \| bHLHa22	musculin (activated B-cell factor-1)	Two-hybrid	BioGRID	16189514
MTCP1	C6.1B	mature T-cell proliferation 1	Two-hybrid	BioGRID	16189514
MTMR9	C8orf9 \| DKFZp434K171 \| LIP-STYX \| MGC126672 \| MTMR8	myotubularin related protein 9	Two-hybrid	BioGRID	16189514
MVK	FLJ96772 \| LRBP \| MK \| MVLK	mevalonate kinase	Two-hybrid	BioGRID	16189514
MYL6	ESMLC \| LC17-GI \| LC17-NM \| LC17A \| LC17B \| MLC1SM \| MLC3NM \| MLC3SM	myosin, light chain 6, alkali, smooth muscle and non-muscle	Two-hybrid	BioGRID	16189514
MYO1F	-	myosin IF	Two-hybrid	BioGRID	16189514
MYOZ2	C4orf5 \| CS-1	myozenin 2	Two-hybrid	BioGRID	16189514
NBPF3	AE2 \| DKFZp434D177	neuroblastoma breakpoint family, member 3	Two-hybrid	BioGRID	16189514
NDUFB1	CI-SGDH \| MNLL	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	Two-hybrid	BioGRID	16189514
NDUFV1	CI-51kD \| UQOR1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	Two-hybrid	BioGRID	16189514
NLE1	FLJ10458 \| Nle	notchless homolog 1 (Drosophila)	Two-hybrid	BioGRID	16189514
NPPB	BNP	natriuretic peptide precursor B	Two-hybrid	BioGRID	16189514
NSUN4	MGC22960 \| RP4-603I14.2	NOL1/NOP2/Sun domain family, member 4	Two-hybrid	BioGRID	16189514
NTNG2	KIAA0625 \| KIAA1857 \| LHLL9381 \| Lmnt2 \| MGC21884 \| NTNG1 \| bA479K20.1	netrin G2	Two-hybrid	BioGRID	16189514
PDHX	DLDBP \| E3BP \| OPDX \| PDX1 \| proX	pyruvate dehydrogenase complex, component X	Two-hybrid	BioGRID	16189514
PGLS	6PGL	6-phosphogluconolactonase	Two-hybrid	BioGRID	16189514
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
POLR2G	MGC138367 \| MGC138369 \| RPB7 \| hRPB19 \| hsRPB7	polymerase (RNA) II (DNA directed) polypeptide G	-	HPRD	9704926
POU4F1	BRN3A \| FLJ13449 \| Oct-T1 \| RDC-1	POU class 4 homeobox 1	-	HPRD,BioGRID	12432261
PRTFDC1	FLJ11888 \| HHGP	phosphoribosyl transferase domain containing 1	Two-hybrid	BioGRID	16189514
PRUNE2	A214N16.3 \| BMCC1 \| BNIPXL \| C9orf65 \| DKFZp762K117 \| FLJ50060 \| FLJ54876 \| FLJ59118 \| KIAA0367 \| RP11-58J3.2 \| bA214N16.3	prune homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	10322114
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Affinity Capture-MS	BioGRID	17353931
RAB37	FLJ30284 \| FLJ32507	RAB37, member RAS oncogene family	Two-hybrid	BioGRID	16189514
RAD23A	HHR23A \| MGC111083	RAD23 homolog A (S. cerevisiae)	Two-hybrid	BioGRID	16189514
RALYL	HNRPCL3	RALY RNA binding protein-like	Two-hybrid	BioGRID	16189514
RASL11B	MGC2827 \| MGC4499	RAS-like, family 11, member B	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
RHOXF2	PEPP-2 \| PEPP2 \| THG1	Rhox homeobox family, member 2	Two-hybrid	BioGRID	16189514
RMND5B	DKFZp434K0926 \| FLJ22318	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	Two-hybrid	BioGRID	16189514
RNF183	FLJ31197 \| MGC4734	ring finger protein 183	Two-hybrid	BioGRID	16189514
RP4-691N24.1	FLJ11792 \| KIAA0980 \| NLP \| dJ691N24.1	ninein-like	Two-hybrid	BioGRID	16189514
RPL31	MGC88191	ribosomal protein L31	Two-hybrid	BioGRID	16189514
RPS15A	FLJ27457 \| MGC111208 \| S15a	ribosomal protein S15a	Two-hybrid	BioGRID	16189514
SALL2	FLJ10414 \| FLJ55746 \| HSAL2 \| KIAA0360 \| ZNF795 \| p150(Sal2)	sal-like 2 (Drosophila)	Two-hybrid	BioGRID	16189514
SELI	KIAA1724	selenoprotein I	Two-hybrid	BioGRID	16189514
SERP2	C13orf21 \| MGC35505 \| RP11-269C23.1 \| bA269C23.1	stress-associated endoplasmic reticulum protein family member 2	Two-hybrid	BioGRID	16189514
SF1	D11S636 \| ZFM1 \| ZNF162	splicing factor 1	-	HPRD,BioGRID	9660765
SLC1A1	EAAC1 \| EAAT3	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Two-hybrid	BioGRID	16189514
SLC22A24	MGC34821	solute carrier family 22, member 24	Two-hybrid	BioGRID	16189514
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	Two-hybrid	BioGRID	16189514
SMNDC1	SMNR \| SPF30	survival motor neuron domain containing 1	Affinity Capture-MS	BioGRID	17353931
SNRPC	FLJ20302	small nuclear ribonucleoprotein polypeptide C	-	HPRD,BioGRID	10827180
SSBP2	DKFZp686F03273 \| HSPC116	single-stranded DNA binding protein 2	Two-hybrid	BioGRID	16189514
SUV39H2	FLJ23414 \| KMT1B	suppressor of variegation 3-9 homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD	9488465
TMSB4Y	MGC26307 \| TB4Y	thymosin beta 4, Y-linked	Two-hybrid	BioGRID	16189514
TRIM37	KIAA0898 \| MUL \| POB1 \| TEF3	tripartite motif-containing 37	Two-hybrid	BioGRID	16189514
TRPV5	CAT2 \| ECAC1 \| OTRPC3	transient receptor potential cation channel, subfamily V, member 5	Two-hybrid	BioGRID	16189514
TSPAN3	TM4-A \| TM4SF8 \| TSPAN-3	tetraspanin 3	Two-hybrid	BioGRID	16189514
TULP2	TUBL2	tubby like protein 2	Two-hybrid	BioGRID	16189514
VPS72	CFL1 \| Swc2 \| TCFL1 \| YL-1 \| YL1	vacuolar protein sorting 72 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
WDR37	FLJ40354 \| KIAA0982 \| RP11-529L18.2	WD repeat domain 37	Two-hybrid	BioGRID	16189514
WWP1	AIP5 \| DKFZp434D2111 \| Tiul1 \| hSDRP1	WW domain containing E3 ubiquitin protein ligase 1	Two-hybrid	BioGRID	16189514
WWP2	AIP2 \| WWp2-like	WW domain containing E3 ubiquitin protein ligase 2	Two-hybrid	BioGRID	16189514
YY1AP1	FLJ10875 \| FLJ13914 \| HCCA1 \| HCCA2 \| YAP \| YY1AP	YY1 associated protein 1	Two-hybrid	BioGRID	16189514
ZDHHC3	DKFZp313D2314 \| FLJ20209 \| FLJ45940 \| GODZ \| ZNF373	zinc finger, DHHC-type containing 3	Two-hybrid	BioGRID	16189514
ZNF165	LD65 \| ZSCAN7	zinc finger protein 165	Affinity Capture-Western Two-hybrid	BioGRID	16189514

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_BARD1_PATHWAY	29	19	All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP	404	246	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN	180	101	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22	13	9	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP	309	199	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK	779	480	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN	75	43	All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP	145	91	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN	309	206	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN	337	230	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS	30	20	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP	64	46	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	390	242	All SZGR genes in this pathway
JIANG_VHL_TARGETS	138	91	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN	911	527	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	1011	592	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP	425	253	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN	342	220	All SZGR genes in this pathway
MUELLER_PLURINET	299	189	All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP	149	85	All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP	323	240	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_DN	33	25	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_DN	43	32	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_DN	39	28	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_DN	40	29	All SZGR genes in this pathway
JIANG_HYPOXIA_VIA_VHL	34	24	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-299-5p	46	52	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.