Gene Page: F2R

Summary
GeneID  2149
Symbol  F2R
Synonyms  CF2R|HTR|PAR1|TR
Description  coagulation factor II (thrombin) receptor
See related  HGNC:3537|MIM:187930|Ensembl:ENSG00000181104|HPRD:01763|
Locus tag  -
Gene type  protein-coding
Map location  5q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0081 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)1672265 
GO:0004872receptor activityIEA-
GO:0015057thrombin receptor activityTAS9038223 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002248connective tissue replacement during inflammatory responseIDA9639571 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007262STAT protein nuclear translocationIDA10692450 
GO:0007260tyrosine phosphorylation of STAT proteinIDA10692450 
GO:0007165signal transductionIEA-
GO:0008285negative regulation of cell proliferationIDA10692450 
GO:0030168platelet activationIDA9038223 
GO:0009611response to woundingIDA9639571 
GO:0009653anatomical structure morphogenesisTAS9701242 
GO:0006919caspase activationIDA10692450 
GO:0030194positive regulation of blood coagulationIDA9038223 
GO:0051209release of sequestered calcium ion into cytosolIDA1672265 
GO:0032967positive regulation of collagen biosynthetic processIDA9639571 
GO:0030335positive regulation of cell migrationIMP9701242 
GO:0043410positive regulation of MAPKKK cascadeIDA17848177 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045893positive regulation of transcription, DNA-dependentIDA17848177 
GO:0046427positive regulation of JAK-STAT cascadeIDA10692450 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusTAS7961693 
GO:0005901caveolaIDA17848177 
GO:0005886plasma membraneEXP1851174 |10477691 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1672265 
GO:0031094platelet dense tubular networkIDA9038223 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
F2PTcoagulation factor II (thrombin)Thrombin interacts with PAR1. This interaction was modeled on a demonstrated interaction between Thrombin from an unspecified species and human PAR1.BIND15707890 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12-HPRD,BioGRID8290554 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13Affinity Capture-WesternBioGRID8290554 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD,BioGRID10644723 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2in vitroBioGRID10644723 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)-HPRD11278329 
MMP1CLG | CLGNmatrix metallopeptidase 1 (interstitial collagenase)MMP-1 interacts with PAR1.BIND15707890 
SNX1HsT17379 | MGC8664 | SNX1A | Vps5sorting nexin 1-HPRD,BioGRID12058063 
 


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.