Gene Page: F11

Summary
GeneID  2160
Symbol  F11
Synonyms  FXI|MGC141891
Description  coagulation factor XI
See related  HGNC:3529|MIM:264900|Ensembl:ENSG00000088926|HPRD:07524|
Locus tag  -
Gene type  protein-coding
Map location  4q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTC310.930.88
CHTF180.930.93
WDR900.920.91
HAUS50.920.89
LEPRE10.910.90
LIG10.900.89
CNTROB0.900.90
DVL20.900.89
CPSF10.900.90
POLE0.890.91
Top 10 negatively co-expressed genes
AF347015.31-0.62-0.82
AF347015.27-0.62-0.82
MT-CO2-0.60-0.80
MT-CYB-0.59-0.79
AF347015.33-0.59-0.77
AIFM3-0.58-0.68
AF347015.8-0.58-0.79
C5orf53-0.57-0.67
S100B-0.57-0.72
IFI27-0.57-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityNASglutamate (GO term level: 7)9593722 
GO:0008201heparin bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0007596blood coagulationNAS9593722 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS9593722 
GO:0016020membraneNAS9593722 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
F2PTcoagulation factor II (thrombin)-HPRD1652157 
GP1BABSS | CD42B | CD42b-alpha | GP1B | MGC34595glycoprotein Ib (platelet), alpha polypeptide-HPRD,BioGRID11696542 
KNG1BDK | KNGkininogen 1Reconstituted ComplexBioGRID291905 
-HPRD1652157 |3936495 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD,BioGRID2551064 
SERPINF2A2AP | AAP | ALPHA-2-PI | API | PLIserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2-HPRD8703832 
TFPI2FLJ21164 | PP5 | REF1 | TFPI-2tissue factor pathway inhibitor 2-HPRD8555184 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
BIOCARTA_INTRINSIC_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_PLATELETAPP_PATHWAY 1410All SZGR genes in this pathway
REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE 3222All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY 1712All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
AMUNDSON_GAMMA_RADIATION_RESISTANCE 2014All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP 8550All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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