Gene Page: NLGN1

Summary
GeneID  22871
Symbol  NLGN1
Synonyms  KIAA1070|MGC45115
Description  neuroligin 1
See related  HGNC:14291|MIM:600568|Ensembl:ENSG00000169760|HPRD:07195|
Locus tag  -
Gene type  protein-coding
Map location  3q26.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCOA70.950.90
COL4A3BP0.940.92
CHM0.940.91
PREPL0.940.88
ARFGEF20.930.90
MAP2K40.930.88
PIK3CB0.930.90
DPP80.930.87
ATRNL10.930.90
ATP6V1A0.920.86
Top 10 negatively co-expressed genes
C1orf61-0.50-0.64
RAB34-0.49-0.55
AF347015.21-0.48-0.46
EFEMP2-0.47-0.53
PLA2G5-0.47-0.46
IL32-0.47-0.50
DBI-0.47-0.55
RHOC-0.47-0.58
GATSL3-0.46-0.53
ENHO-0.46-0.54
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042043neurexin bindingISSSynap (GO term level: 4)-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisISSSynap (GO term level: 6)-
GO:0016080synaptic vesicle targetingISSSynap (GO term level: 10)-
GO:0045664regulation of neuron differentiationISSneuron, neurogenesis (GO term level: 9)-
GO:0007155cell adhesionIEA-
GO:0006605protein targetingISS-
GO:0016339calcium-dependent cell-cell adhesionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseISSneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneISS-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)Two-hybridBioGRID9278515 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)Two-hybridBioGRID9278515 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Reconstituted Complex
Two-hybrid		BioGRID9278515 
NRXN1DKFZp313P2036 | FLJ35941 | Hs.22998 | KIAA0578neurexin 1-HPRD,BioGRID8576240 |14522992 
NRXN2FLJ40892 | KIAA0921neurexin 2Reconstituted ComplexBioGRID8576240 
NRXN3KIAA0743 | MGC176711neurexin 3Reconstituted ComplexBioGRID8576240 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497645651m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1901201271A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-1935085141Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-21737431Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-30-5p11201126m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-369-3p164016461Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37416401646m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-381165416601Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-448354360m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p13991405m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4959719771Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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