Gene Page: SCAP

Summary
GeneID  22937
Symbol  SCAP
Synonyms  KIAA0199
Description  SREBF chaperone
See related  HGNC:30634|MIM:601510|Ensembl:ENSG00000114650|HPRD:03300|
Locus tag  -
Gene type  protein-coding
Map location  3p21.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0051082unfolded protein bindingNAS11726962 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0006994positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion responseIMP11726962 
GO:0006629lipid metabolic processIEA-
GO:0019217regulation of fatty acid metabolic processIEA-
GO:0045541negative regulation of cholesterol biosynthetic processNAS11969205 
GO:0045716positive regulation of low-density lipoprotein receptor biosynthetic processNAS11726974 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusNAS11726962 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumNAS11726962 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS11726962 
GO:0031410cytoplasmic vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
INSIG1CL-6 | MGC1405insulin induced gene 1-HPRD,BioGRID12202038 |12482938 
|12842885 
An unspecified isoform of INSIG-1 interacts with SCAP, as a part of the SCAP-SREBP-2 complex. This interaction was modelled on a demonstrated interaction between human INSIG-1 and hamster SCAP.BIND12242332 
INSIG2MGC26273insulin induced gene 2INSIG-2 interacts with SCAP, as a part of the SCAP-SREBP-2 complex. This interaction was modelled on a demonstrated interaction between human INSIG-2 and hamster SCAP.BIND12242332 
-HPRD12242332 |12482938 
PGRMC1HPR6.6 | MPRprogesterone receptor membrane component 1PGRMC1 interacts with SCAP.BIND15782218 
SCAPKIAA0199SREBF chaperoneSCAP homodimerizes.BIND15782218 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2-HPRD10896675 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SA_CASPASE_CASCADE 1913All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
LIN_APC_TARGETS 7755All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_UP 1410All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway


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