Gene Page: TNIK

Summary
GeneID  23043
Symbol  TNIK
Synonyms  -
Description  TRAF2 and NCK interacting kinase
See related  HGNC:30765|MIM:610005|HPRD:18206|
Locus tag  -
Gene type  protein-coding
Map location  3q26.2-q26.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3428 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
XXbac-B461K10.10.920.92
VASH10.910.91
VHL0.910.91
BTBD120.900.92
MICALL10.900.89
TRIO0.900.90
CLIP20.900.92
MLLT10.890.92
AXIN10.890.90
ZCCHC140.890.91
Top 10 negatively co-expressed genes
AF347015.31-0.71-0.82
C5orf53-0.68-0.70
MT-CO2-0.67-0.79
AF347015.27-0.66-0.76
B2M-0.66-0.74
HLA-F-0.66-0.68
COPZ2-0.66-0.74
FXYD1-0.65-0.75
IFI27-0.65-0.75
HIGD1B-0.65-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005083small GTPase regulator activityIEA-
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIDA10521462 
GO:0004674protein serine/threonine kinase activityNAS-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationNAS-
GO:0007254JNK cascadeTAS-
GO:0007243protein kinase cascadeIDA10521462 
GO:0006950response to stressIDA10521462 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD10521462 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD10521462 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene family-HPRD15342639 
SLC9A1APNH | FLJ42224 | NHE1solute carrier family 9 (sodium/hydrogen exchanger), member 1Reconstituted ComplexBioGRID11369779 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID10521462 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
DOANE_BREAST_CANCER_CLASSES_UP 7238All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP 6644All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_DN 126All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway


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