Gene Page: FOXO1

Summary
GeneID  2308
Symbol  FOXO1
Synonyms  FKH1|FKHR|FOXO1A
Description  forkhead box O1
See related  HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|
Locus tag  -
Gene type  protein-coding
Map location  13q14.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0217 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ROBO40.750.80
KIAA12740.750.77
PCDH120.710.72
PIK3R60.710.66
PXN0.700.73
SLC7A50.700.72
AFAP1L10.690.71
AL161668.20.690.72
DAG10.680.71
SLC38A100.680.68
Top 10 negatively co-expressed genes
UQCRB-0.47-0.56
C5orf53-0.47-0.51
USMG5-0.46-0.64
ACOT13-0.45-0.50
NDUFB9-0.45-0.53
SYCP3-0.44-0.47
LY96-0.44-0.49
GSTO1-0.44-0.53
COX7B-0.44-0.49
SPHAR-0.43-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIPI11353774 |17202144 |18408765 
GO:0016563transcription activator activityIDA7862145 |10871843 |12228231 
GO:0043565sequence-specific DNA bindingIDA12228231 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001568blood vessel developmentIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0008286insulin receptor signaling pathwayIEA-
GO:0006916anti-apoptosisIDA10871843 
GO:0042127regulation of cell proliferationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA10871843 |12228231 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA11311120 |12228231 
GO:0005737cytoplasmIDA11311120 |12228231 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID12482965 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)FoxO1 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and p21Cip1 promoter from an unspecified species.BIND15084259 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID11893744 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID10973497 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDabeta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.BIND15905404 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID11435445 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2FOXO1A interacts with FHL2.BIND15692560 
FOXG1BF1 | BF2 | FHKL3 | FKH2 | FKHL1 | FKHL2 | FKHL3 | FKHL4 | FOXG1A | FOXG1B | FOXG1C | HBF-1 | HBF-2 | HBF-3 | HBF-G2 | HBF2 | HFK1 | HFK2 | HFK3 | KHL2 | QINforkhead box G1FoxO1 interacts with FoxG1. This interaction was modelled on an interaction demonstrated between FoxO1 from an unspecified species and mouse FoxG1.BIND15084259 
G6PCG6PT | GSD1 | GSD1a | MGC163350glucose-6-phosphatase, catalytic subunit-HPRD11672436 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alpha-HPRD,BioGRID12519792 
HOXA5HOX1 | HOX1.3 | HOX1C | MGC9376homeobox A5-HPRD,BioGRID12163409 
SIRT1SIR2L1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)FOXO1A interacts with SIRT1.BIND15692560 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3FoxO1 interacts with Smad3. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and Smad3 from an unspecified species.BIND15084259 
-HPRD,BioGRID15084259 
SMAD4DPC4 | JIP | MADH4SMAD family member 4FoxO1 interacts with Smad4.BIND15084259 
-HPRD,BioGRID15084259 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10973497 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-Western
Co-localization
Reconstituted Complex		BioGRID17077083 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD,BioGRID11237865 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID11237865 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
BIOCARTA_AKT_PATHWAY 2216All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 3729All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_HDAC_CLASSIII_PATHWAY 2520All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 2920All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
BARRIER_COLON_CANCER_RECURRENCE_UP 4228All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_UP 12171All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_DN 3021All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN 4331All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
ALONSO_METASTASIS_DN 2617All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
GU_PDEF_TARGETS_DN 3920All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_UP 6644All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1284264321Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-135325532621A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1392212271Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-142-3p2742801Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-144424430m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-145909915m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15325652571m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1822652711Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-183236242m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1948328381Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-27426432m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-369-3p262226291A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37426232629m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-378*66721Ahsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-381324832541Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-486658664m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-493-5p32643270m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4956896951Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-5442902971A,m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
miR-969751Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-962642711A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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