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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: HIC2

Summary

GeneID

23119

Symbol

HIC2

Synonyms

HRG22|KIAA1020|ZBTB30

Description

hypermethylated in cancer 2

Locus tag

Gene type

protein-coding

Map location

22q11.21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

NAS

11554746

GO:0008270

zinc ion binding

IEA

GO:0008022

protein C-terminus binding

IPI

12052894

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006350

transcription

IEA

GO:0045892

negative regulation of transcription, DNA-dependent

NAS

11554746

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005634

nucleus

IDA

11554746

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP	177	110	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP	418	263	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN	88	53	All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP	176	123	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN	1375	806	All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_UP	67	37	All SZGR genes in this pathway
PEREZ_TP53_TARGETS	1174	695	All SZGR genes in this pathway
PEREZ_TP63_TARGETS	355	243	All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS	205	145	All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_2	42	31	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
KORKOLA_TERATOMA	39	25	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
LIAO_HAVE_SOX4_BINDING_SITES	40	26	All SZGR genes in this pathway
LIAO_METASTASIS	539	324	All SZGR genes in this pathway
CHEOK_RESPONSE_TO_HD_MTX_DN	24	18	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP	101	69	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	681	420	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3	720	440	All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_DN	101	65	All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP	113	70	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP	605	377	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN	222	147	All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_DN	187	109	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP	116	87	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_36HR	29	23	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D	882	506	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	4145	4152	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	4023	4030	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-103/107	4190	4197	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	4190	4197	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-125/351	3800	3807	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	3800	3807	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-129-5p	3475	3482	1A,m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-132/212	4670	4676	1A	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	4670	4676	1A	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-133	3910	3917	1A,m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	3910	3917	1A,m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-134	4105	4111	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-135	3541	3547	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	3541	3547	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a	3331	3337	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	3331	3337	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	939	946	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-145	939	946	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-146	2572	2578	m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	2572	2578	m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-181	693	700	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-185	4624	4631	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-199	3680	3686	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	3680	3686	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	3673	3679	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-204/211	3907	3913	m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	3907	3913	m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-208	4646	4652	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-218	2724	2730	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-24	2958	2964	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-299-5p	2717	2723	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	2792	2799	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	147	153	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p	3360	3366	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-335	1153	1159	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-423	3444	3450	m8	hsa-miR-423	AGCUCGGUCUGAGGCCCCUCAG
miR-450	3475	3481	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-485-5p	1647	1654	1A,m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-485-5p	1647	1654	1A,m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-490	4340	4346	m8	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-493-5p	4653	4659	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-499	4645	4652	1A,m8	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-539	3378	3385	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-543	2600	2606	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-9	3004	3011	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
				hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
				hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	2148	2155	1A,m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.