Gene Page: SMG6

Summary
GeneID  23293
Symbol  SMG6
Synonyms  C17orf31|EST1A|KIAA0732|SMG-6
Description  Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
See related  HGNC:17809|MIM:610963|Ensembl:ENSG00000070366|HPRD:06502|
Locus tag  -
Gene type  protein-coding
Map location  17p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NME30.750.74
HDHD30.740.74
GAMT0.720.75
PSMG40.720.72
BOLA10.710.70
ILVBL0.710.73
POMGNT10.700.68
NTHL10.690.71
C9orf1420.690.67
RANGRF0.690.61
Top 10 negatively co-expressed genes
MT-ATP8-0.41-0.48
AF347015.2-0.40-0.42
AF347015.15-0.39-0.43
AF347015.8-0.39-0.43
AF347015.26-0.39-0.45
AF347015.18-0.38-0.45
COBLL1-0.38-0.37
ABCG2-0.37-0.41
MT-CYB-0.36-0.42
CALD1-0.36-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI12699629 
GO:0004519endonuclease activityIEA-
GO:0016787hydrolase activityIEA-
GO:0042162telomeric DNA bindingIDA12699629 
GO:0030145manganese ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS16488880 
GO:0000723telomere maintenanceIMP12699629 
GO:0006406mRNA export from nucleusTAS16488880 
GO:0035303regulation of dephosphorylationTAS15721257 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000781chromosome, telomeric regionIEA-
GO:0005634nucleusIDA14636577 
GO:0005694chromosomeIEA-
GO:0005697telomerase holoenzyme complexTAS12699629 
GO:0005737cytoplasmIDA14636577 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
SMG5EST1B | FLJ34864 | KIAA1089 | LPTS-RP1 | LPTSRP1 | RP11-54H19.7 | SMG-5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)-HPRD12699629 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptase-HPRD,BioGRID12699629 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)UPF1 interacts with SMG6.BIND15721257 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 17657All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_UP 2814All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC2 3925All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_UP 3827All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-199814m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-299-5p1121181Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-71221281Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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