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GeneID |
23411
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Symbol |
SIRT1
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Synonyms |
SIR2L1
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Description |
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
See related |
HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381| |
Locus tag |
RP11-57G10.3 |
Gene type |
protein-coding |
Map location |
10q21.3 |
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Gene set name |
Method of gene set |
Evidence |
Info |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
AC008073.1 | 0.90 | 0.89 | | |
ERH | 0.90 | 0.91 | | |
RPL17P20 | 0.87 | 0.88 | | |
SARNP | 0.87 | 0.87 | | |
PSMA2 | 0.86 | 0.87 | | |
C18orf21 | 0.86 | 0.86 | | |
RPL6P10 | 0.85 | 0.87 | | |
RPL26L1 | 0.85 | 0.87 | | |
PSMB7 | 0.85 | 0.86 | | |
EIF3M | 0.85 | 0.88 | | |
Top 10 negatively co-expressed genes | AF347015.15 | -0.61 | -0.71 | | |
AF347015.8 | -0.60 | -0.69 | | |
AF347015.27 | -0.60 | -0.68 | | |
MT-CYB | -0.60 | -0.69 | | |
TINAGL1 | -0.60 | -0.69 | | |
AF347015.26 | -0.59 | -0.73 | | |
SLC6A12 | -0.59 | -0.68 | | |
AF347015.2 | -0.59 | -0.70 | | |
EPAS1 | -0.59 | -0.70 | | |
AF347015.33 | -0.58 | -0.67 | | |
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Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0003950 | NAD+ ADP-ribosyltransferase activity | TAS | | 10381378 |
GO:0003677 | DNA binding | IEA | | - |
GO:0008270 | zinc ion binding | IEA | | - |
GO:0008022 | protein C-terminus binding | IPI | | 18203716 |
GO:0017136 | NAD-dependent histone deacetylase activity | IDA | | 16959573 |
GO:0016564 | transcription repressor activity | IEA | | - |
GO:0051287 | NAD binding | IEA | | - |
GO:0019213 | deacetylase activity | IDA | | 18203716 |
GO:0046872 | metal ion binding | IEA | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007519 | skeletal muscle development | IEA | neuron (GO term level: 8) | - |
GO:0001542 | ovulation from ovarian follicle | IEA | | - |
GO:0006355 | regulation of transcription, DNA-dependent | IEA | | - |
GO:0006471 | protein amino acid ADP-ribosylation | TAS | | 10381378 |
GO:0006342 | chromatin silencing | TAS | | 10381378 |
GO:0007283 | spermatogenesis | IEA | | - |
GO:0006974 | response to DNA damage stimulus | IDA | | 18203716 |
GO:0006915 | apoptosis | IEA | | - |
GO:0007275 | multicellular organismal development | IEA | | - |
GO:0016481 | negative regulation of transcription | IEA | | - |
GO:0030154 | cell differentiation | IEA | | - |
GO:0033158 | regulation of protein import into nucleus, translocation | IMP | | 18203716 |
GO:0051097 | negative regulation of helicase activity | IDA | | 18203716 |
GO:0016575 | histone deacetylation | IEA | | - |
GO:0044419 | interspecies interaction between organisms | IEA | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0005634 | nucleus | IEA | | - |
GO:0005677 | chromatin silencing complex | IEA | | - |
GO:0005737 | cytoplasm | IDA | | 18029348 |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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