Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: HEY2

Summary

GeneID

23493

Symbol

HEY2

Synonyms

CHF1|GRIDLOCK|GRL|HERP1|HESR2|HRT2|MGC10720|bHLHb32

Description

hairy/enhancer-of-split related with YRPW motif 2

Locus tag

Gene type

protein-coding

Map location

6q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003677

DNA binding

IEA

GO:0003700

transcription factor activity

TAS

10415358

GO:0005515

protein binding

IEA

GO:0030528

transcription regulator activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

TAS

neurite (GO term level: 5)

10415358

GO:0001570

vasculogenesis

IEA

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0007219

Notch signaling pathway

IEA

GO:0009887

organ morphogenesis

TAS

10415358

GO:0007275

multicellular organismal development

IEA

GO:0045746

negative regulation of Notch signaling pathway

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
HAND1	Hxt \| Thing1 \| bHLHa27 \| eHand	heart and neural crest derivatives expressed 1	Reconstituted Complex	BioGRID	10924525
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	11486045
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	Affinity Capture-Western	BioGRID	11486045
HES1	FLJ20408 \| HES-1 \| HHL \| HRY \| bHLHb39	hairy and enhancer of split 1, (Drosophila)	-	HPRD,BioGRID	11486045
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	-	HPRD,BioGRID	11486045
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-Western	BioGRID	11486045
SIRT1	SIR2L1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	-	HPRD,BioGRID	12535671

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_P73PATHWAY	79	59	All SZGR genes in this pathway
PID_HES_HEY_PATHWAY	48	39	All SZGR genes in this pathway
REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	46	28	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1	70	46	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH	103	64	All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN	244	147	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN	74	44	All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP	443	294	All SZGR genes in this pathway
PEREZ_TP63_TARGETS	355	243	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN	42	32	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1	528	324	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	138	92	All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN	67	46	All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP	229	149	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP	271	165	All SZGR genes in this pathway
RAFFEL_VEGFA_TARGETS_UP	9	8	All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN	99	74	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1376	1382	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-144	1376	1382	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-153	1417	1424	1A,m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	1101	1108	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-22	196	202	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-448	1418	1424	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.