Gene Page: CABIN1

Summary
GeneID  23523
Symbol  CABIN1
Synonyms  CAIN|KIAA0330|PPP3IN
Description  calcineurin binding protein 1
See related  HGNC:24187|MIM:604251|Ensembl:ENSG00000099991|HPRD:10369|
Locus tag  -
Gene type  protein-coding
Map location  22q11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.7575 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTGES20.920.94
STUB10.900.94
HAGH0.900.92
ADAP10.900.90
RAB4B0.890.89
ABHD80.890.92
RUNDC3A0.890.91
PDXP0.880.89
SNRPN0.880.91
SH3BP10.870.88
Top 10 negatively co-expressed genes
EIF5B-0.53-0.61
THOC2-0.45-0.43
CCAR1-0.44-0.39
AC005921.3-0.44-0.64
ANKRD36B-0.44-0.55
SFRS18-0.43-0.55
NSBP1-0.43-0.40
ANKRD36-0.42-0.54
ZNF560-0.42-0.44
SFRS12-0.42-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005488bindingIEA-
GO:0004864protein phosphatase inhibitor activityNAS9655484 
GO:0008170N-methyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006306DNA methylationIEA-
GO:0007166cell surface receptor linked signal transductionNAS9655484 
GO:0016568chromatin modificationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AMPHAMPH1amphiphysin-HPRD,BioGRID10931822 
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunit-HPRD,BioGRID10931822 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)CALM1 (CaM) interacts with CABIN1. This interaction was modelled on a demonstrated interaction between CaM from an unspecified species and human CABIN1.BIND15902271 
CAMK4CaMK-GR | MGC36771calcium/calmodulin-dependent protein kinase IVCAMK4 (CAMKIV) interacts with CABIN1.BIND15902271 
DNM1DNMdynamin 1-HPRD,BioGRID10931822 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID10933397 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID10933397 
MEF2BFLJ32599 | FLJ46391 | MGC189732 | MGC189763 | RSRFR2myocyte enhancer factor 2B-HPRD,BioGRID10531067 |12700764 
MEF2DDKFZp686I1536myocyte enhancer factor 2DAffinity Capture-Western
Reconstituted Complex		BioGRID10531067 |10933397 
MEF2D interacts with CABIN1.BIND15902271 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoformTwo-hybridBioGRID9655484 
-HPRD11714752 
PPP3CBCALNA2 | CALNBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform-HPRD11714752 
-HPRD9655484 
PPP3CCCALNA3protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform-HPRD11714752 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)-HPRD,BioGRID10933397 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideYWHAQ (14-3-3-theta) interacts with phosphorylated CABIN1. This interaction was modelled on a demonstrated interaction between mouse 14-3-3-theta and human CABIN1.BIND15902271 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_MEF2D_PATHWAY 2316All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_MCF10A 4326All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway


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