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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: BACE1

Summary

GeneID

23621

Symbol

BACE1

Synonyms

ASP2|BACE|FLJ90568|HSPC104|KIAA1149

Description

beta-site APP-cleaving enzyme 1

Locus tag

Gene type

protein-coding

Map location

11q23.2-q23.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.006

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004190

aspartic-type endopeptidase activity

IDA

10531052

GO:0004190

aspartic-type endopeptidase activity

IEA

GO:0008798

beta-aspartyl-peptidase activity

TAS

10591214

GO:0008233

peptidase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006508

proteolysis

IDA

10531052

GO:0006508

proteolysis

IEA

GO:0006509

membrane protein ectodomain proteolysis

TAS

12354787

GO:0050435

beta-amyloid metabolic process

IDA

15080893

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0030424

axon

IEA

neuron, axon, Neurotransmitter (GO term level: 6)

GO:0005794

Golgi apparatus

IDA

10531052

GO:0005768

endosome

IDA

10531052

GO:0016020

membrane

IEA

GO:0005887

integral to plasma membrane

TAS

10887202

GO:0031410

cytoplasmic vesicle

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATP1B1	ATP1B \| MGC1798	ATPase, Na+/K+ transporting, beta 1 polypeptide	BACE1 interacts with ATP1B1 (Na/K-ATPase, beta-subunit). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human Na/K-ATPase, beta-subunit.	BIND	15606899
CMPK1	CMK \| CMPK \| UMK \| UMP-CMPK \| UMPK	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	BACE1 interacts with UMP-CMPK. This interaction was modelled on a demonstrated interaction between mouse BACE1 and human UMP-CMPK.	BIND	15606899
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	-	HPRD	12135764
ITM2C	BRI3 \| BRICD2C \| E25 \| E25C \| ITM3	integral membrane protein 2C	-	HPRD	15606899
ITM2C	BRI3 \| BRICD2C \| E25 \| E25C \| ITM3	integral membrane protein 2C	BACE1 interacts with ITM2C (BRI3).	BIND	15606899
KHSRP	FBP2 \| FUBP2 \| KSRP \| MGC99676	KH-type splicing regulatory protein	BACE1 interacts with KHSRP. This interaction was modelled on a demonstrated interaction between mouse BACE1 and human KHSRP.	BIND	15606899
MMP2	CLG4 \| CLG4A \| MMP-II \| MONA \| TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	-	HPRD	12586836
NCSTN	APH2 \| KIAA0253	nicastrin	Nicastrin interacts with BACE1.	BIND	12054507
NCSTN	APH2 \| KIAA0253	nicastrin	-	HPRD,BioGRID	12054507
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	BACE1 interacts with PDIA3 (ERp60). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human PDIA3.	BIND	15606899
PSAP	FLJ00245 \| GLBA \| MGC110993 \| SAP1	prosaposin	BACE1 interacts with PSAP (prosaposin). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human prosaposin.	BIND	15606899
RANBP9	RANBPM	RAN binding protein 9	BACE1 interacts with RANBP9 (RANBPM). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human RANBPM.	BIND	15606899

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ALZHEIMERS_DISEASE	169	110	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP	285	181	All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN	121	84	All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN	352	225	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN	141	84	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_UP	33	20	All SZGR genes in this pathway
PEREZ_TP53_TARGETS	1174	695	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP	769	437	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP	266	171	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	393	244	All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN	60	38	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN	191	123	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP	111	70	All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2	356	214	All SZGR genes in this pathway
GYORFFY_DOXORUBICIN_RESISTANCE	56	34	All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP	387	225	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN	418	245	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	3526	3533	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	3526	3532	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	3526	3532	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-135	1722	1729	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1722	1729	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a	1551	1558	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1551	1558	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	267	273	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-19	3448	3455	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	3448	3455	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-214	431	437	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-24*	2904	2910	1A	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-29	1052	1058	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-299-5p	1728	1734	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-3p	2188	2194	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	2188	2194	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-369-3p	2156	2163	1A,m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	2157	2163	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-378*	2819	2825	m8	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	2819	2825	m8	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-7	992	998	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-9	2732	2739	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.