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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ALK

Summary

GeneID

238

Symbol

ALK

Synonyms

CD246|Ki-1|TFG/ALK

Description

anaplastic lymphoma receptor tyrosine kinase

Locus tag

Gene type

protein-coding

Map location

2p23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

TBXAS1

0.87

0.83

C3AR1

0.86

0.80

P2RY12

0.81

0.79

C1QC

0.81

0.83

LAPTM5

0.80

0.84

ADORA3

0.80

0.82

RNASE6

0.78

0.82

CD53

0.77

0.80

0.77

0.82

GPR34

0.77

0.80

Top 10 negatively co-expressed genes

SH3BP2

-0.34

-0.42

ZNF814

-0.34

-0.40

ZNF418

-0.34

-0.31

KIAA1949

-0.33

-0.30

VAV2

-0.33

-0.27

GJC1

-0.33

-0.32

AC004017.1

-0.33

-0.25

AL033532.1

-0.33

-0.26

AC010522.1

-0.33

-0.39

UPF3A

-0.33

-0.39

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004714

transmembrane receptor protein tyrosine kinase activity

IDA

neurite (GO term level: 8)

9174053

GO:0000166

nucleotide binding

IEA

GO:0004872

receptor activity

IEA

GO:0004716

receptor signaling protein tyrosine kinase activity

TAS

9053841

GO:0005515

protein binding

IEA

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007420

brain development

TAS

Brain (GO term level: 7)

9053841

GO:0007399

nervous system development

IMP

neurite (GO term level: 5)

11121404

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

IEA

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006487

protein amino acid N-linked glycosylation

IMP

9174053

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016020

membrane

IEA

GO:0005887

integral to plasma membrane

TAS

9053841

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	11888936
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD	9174053
JAK3	JAK-3 \| JAK3_HUMAN \| JAKL \| L-JAK \| LJAK	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	11850821
NPM1	B23 \| MGC104254 \| NPM	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	-	HPRD	11888936
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	Affinity Capture-Western	BioGRID	11888936
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD	9174053
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	-	HPRD,BioGRID	11278720
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	9174053
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Affinity Capture-Western	BioGRID	11888936
SHC1	FLJ26504 \| SHC \| SHCA		-	HPRD	9174053
SHC3	N-Shc \| NSHC \| RAI \| SHCC	SHC (Src homology 2 domain containing) transforming protein 3	-	HPRD,BioGRID	12185581

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP	59	38	All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP	332	228	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP	255	177	All SZGR genes in this pathway
DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP	64	37	All SZGR genes in this pathway
HOOI_ST7_TARGETS_DN	123	78	All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN	143	83	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP	276	165	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP	139	83	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP	341	197	All SZGR genes in this pathway
LASTOWSKA_COAMPLIFIED_WITH_MYCN	43	29	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
CHEN_NEUROBLASTOMA_COPY_NUMBER_GAINS	50	35	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP	430	288	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP	323	240	All SZGR genes in this pathway
TAVAZOIE_METASTASIS	108	68	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	349	234	All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3	341	243	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-96	107	113	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.