Gene Page: FYB

Summary
GeneID  2533
Symbol  FYB
Synonyms  ADAP|PRO0823|SLAP-130
Description  FYN binding protein (FYB-120/130)
See related  HGNC:4036|MIM:602731|HPRD:04107|
Locus tag  -
Gene type  protein-coding
Map location  5p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BBX0.910.88
QKI0.900.90
JAM30.870.82
MAGT10.870.83
TMTC20.850.88
SPG200.850.86
THBS20.850.85
MEGF100.840.89
MOBKL2B0.840.84
MPP50.840.87
Top 10 negatively co-expressed genes
TBC1D10A-0.38-0.37
ST20-0.38-0.45
FAM128A-0.35-0.38
NANOS3-0.35-0.44
IL32-0.35-0.39
C1orf86-0.34-0.36
RP9P-0.34-0.47
AC016757.1-0.33-0.33
PHPT1-0.33-0.40
AC009171.1-0.33-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)10747096 
GO:0009045xylose isomerase activityIEA-
GO:0005515protein bindingTAS9207119 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS9207119 
GO:0007243protein kinase cascadeTAS9207119 
GO:0005975carbohydrate metabolic processIEA-
GO:0007165signal transductionTAS9207119 
GO:0006607NLS-bearing substrate import into nucleusTAS9207119 
GO:0008150biological_processND-
GO:0006955immune responseTAS9207119 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9207119 
GO:0005737cytoplasmIEA-
GO:0015629actin cytoskeletonTAS10747096 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ENAHENA | MENA | NDPP1enabled homolog (Drosophila)-HPRD10747096 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD7504057 |9207119 
-HPRD,BioGRID7504057 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD10497204 
-HPRD9115214 |9207119 
|10497204 
SH2D1ADSHP | EBVS | FLJ18687 | FLJ92177 | IMD5 | LYP | MTCP1 | SAP | XLP | XLPDSH2 domain protein 1A-HPRD12458214 
SKAP1SCAP1 | SKAP55src kinase associated phosphoprotein 1-HPRD,BioGRID9748251 
SKAP2MGC10411 | MGC33304 | PRAP | RA70 | SAPS | SCAP2 | SKAP-HOM | SKAP55Rsrc kinase associated phosphoprotein 2-HPRD9671755 
VASP-vasodilator-stimulated phosphoprotein-HPRD,BioGRID10747096 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID10747096 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS 1210All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT 10873All SZGR genes in this pathway
ROSS_AML_WITH_CBFB_MYH11_FUSION 5232All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_DN 6435All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP 14175All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN 2715All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
CHIARETTI_T_ALL_REFRACTORY_TO_THERAPY 3018All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_UP 3930All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway


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