Gene Page: PCSK9

Summary
GeneID  255738
Symbol  PCSK9
Synonyms  FH3|HCHOLA3|LDLCQ1|NARC-1|NARC1
Description  proprotein convertase subtilisin/kexin type 9
See related  HGNC:20001|MIM:607786|Ensembl:ENSG00000169174|HPRD:07080|
Locus tag  -
Gene type  protein-coding
Map location  1p32.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityNASglutamate (GO term level: 7)12730697 
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
GO:0042802identical protein bindingIEA-
GO:0050750low-density lipoprotein receptor bindingIDA17080197 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0022008neurogenesisISSneurogenesis (GO term level: 6)12552133 
GO:0030182neuron differentiationISSneuron (GO term level: 8)12552133 
GO:0043525positive regulation of neuron apoptosisIMPneuron (GO term level: 9)17051583 
GO:0001889liver developmentISS12552133 
GO:0001822kidney developmentISS12552133 
GO:0006508proteolysisIEA-
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0009267cellular response to starvationISS16407292 
GO:0006644phospholipid metabolic processIEA-
GO:0006641triacylglycerol metabolic processIEA-
GO:0006629lipid metabolic processIEA-
GO:0016540protein autoprocessingIDA14622975 
GO:0016540protein autoprocessingTAS16912035 
GO:0042157lipoprotein metabolic processIEA-
GO:0032869cellular response to insulin stimulusISS12552133 
GO:0043086negative regulation of catalytic activityIEA-
GO:0032803regulation of low-density lipoprotein receptor catabolic processIEA-
GO:0042632cholesterol homeostasisIMP17170371 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA12552133 |16912035 |17080197 
 


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