Gene Page: MLH3

Summary
GeneID  27030
Symbol  MLH3
Synonyms  HNPCC7|MGC138372
Description  mutL homolog 3 (E. coli)
See related  HGNC:7128|MIM:604395|Ensembl:ENSG00000119684|HPRD:05094|
Locus tag  -
Gene type  protein-coding
Map location  14q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MICAL10.870.84
ZNF3110.860.86
ZNF1330.860.83
ADAMTS100.860.82
B4GALNT40.850.82
PLSCR30.850.81
NAGK0.840.84
ANKZF10.840.82
RBM50.840.83
QTRT10.840.82
Top 10 negatively co-expressed genes
HLA-F-0.64-0.71
FBXO2-0.62-0.66
CA4-0.62-0.75
ALDOC-0.62-0.70
PTH1R-0.61-0.68
CSRP1-0.60-0.71
TINAGL1-0.60-0.68
C5orf53-0.60-0.70
PTGDS-0.60-0.69
LDHD-0.60-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003696satellite DNA bindingTAS10615123 
GO:0005515protein bindingNAS12095912 
GO:0005524ATP bindingIEA-
GO:0030983mismatched DNA bindingIEA-
GO:0019237centromeric DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007130synaptonemal complex assemblyIEASynap (GO term level: 11)-
GO:0007131reciprocal meiotic recombinationNAS12095912 
GO:0007140male meiosisIEA-
GO:0007144female meiosis IIEA-
GO:0006298mismatch repairIEA-
GO:0006298mismatch repairNAS12095912 
GO:0008104protein localizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000793condensed chromosomeIEA-
GO:0000795synaptonemal complexIEA-
GO:0005634nucleusTAS10615123 
GO:0005712chiasmaIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MLH1COCA2 | FCC2 | HNPCC | HNPCC2 | MGC5172 | hMLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)-HPRD,BioGRID11292842 
hMLH1 interacts with hMLH3.BIND11292842 
MSH4-mutS homolog 4 (E. coli)-HPRD,BioGRID12095912 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MISMATCH_REPAIR 2314All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_MEIOTIC_RECOMBINATION 8662All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE 4828All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
MATZUK_MEIOTIC_AND_DNA_REPAIR 3926All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_DN 5535All SZGR genes in this pathway


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