Gene Page: LAT

Summary
GeneID  27040
Symbol  LAT
Synonyms  LAT1|pp36
Description  linker for activation of T cells
See related  HGNC:18874|MIM:602354|Ensembl:ENSG00000213658|HPRD:03832|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CCDC80.820.49
EFNA40.800.62
NECAP20.800.62
PDPN0.780.52
RASSF100.770.52
CD990.770.66
ABHD40.770.64
RFX20.760.51
SIX50.760.62
SULT1C40.750.62
Top 10 negatively co-expressed genes
NDRG1-0.37-0.50
FBXW7-0.37-0.50
AC016910.1-0.36-0.53
AC079953.2-0.34-0.50
MEF2C-0.34-0.51
ARHGAP20-0.33-0.48
DOCK9-0.32-0.44
C1orf115-0.32-0.40
LMO7-0.32-0.50
DYNC1I1-0.32-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityIDA9489702 
GO:0005515protein bindingIPI16938345 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043303mast cell degranulationIEAserotonin (GO term level: 9)-
GO:0007265Ras protein signal transductionIMP12646565 
GO:0007242intracellular signaling cascadeIDA12646565 
GO:0007229integrin-mediated signaling pathwayIDA15100278 
GO:0006955immune responseIDA15100278 
GO:0019722calcium-mediated signalingIMP12646565 
GO:0050863regulation of T cell activationIMP12646565 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001772immunological synapseIDASynap (GO term level: 7)12646565 
GO:0016021integral to membraneIDA12646565 
GO:0005886plasma membraneEXP11048639 |11607830 |17652306 
GO:0005886plasma membraneIEA-
GO:0045121membrane raftTAS14722116 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD2442B4 | NAIL | NKR2B4 | Nmrk | SLAMF4CD244 molecule, natural killer cell receptor 2B4-HPRD12077228 
CD4CD4mutCD4 molecule-HPRD10562325 
CD8ACD8 | Leu2 | MAL | p32CD8a molecule-HPRD10562325 
CLYBLCLB | bA134O15.1citrate lyase beta likeAffinity Capture-WesternBioGRID11368773 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID10781611 
FCGR2ACD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032Fc fragment of IgG, low affinity IIa, receptor (CD32)-HPRD,BioGRID10781611 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11572860 
GRAPMGC64880GRB2-related adaptor proteinAffinity Capture-Western
Reconstituted Complex		BioGRID9489702 |12186560 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2-HPRD,BioGRID10021361 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD9489702 |12359715 
Affinity Capture-Western
Reconstituted Complex		BioGRID9489702 |11368773 
|12186560 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinase-HPRD10506192|12186560 
Affinity Capture-Western
Biochemical Activity		BioGRID10506192 |12186560 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD9489702 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Reconstituted Complex		BioGRID11368773 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID9729044 |11368773 
LAT interacts with an unspecified isoform of PLC-gamma-1.BIND15696170 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD,BioGRID10469124 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD,BioGRID11259588 
SH3BP23BP2 | CRBM | CRPM | FLJ42079 | RES4-23SH3-domain binding protein 2-HPRD,BioGRID11390470 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD,BioGRID12084069 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID10449770 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseBiochemical ActivityBioGRID11368773 
-HPRD9891970 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID11368773 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaBiochemical ActivityBioGRID11368773 |12186560 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 3125All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_DN 1816All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN 7252All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE 7848All SZGR genes in this pathway


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