Gene Page: GRK6

Summary
GeneID  2870
Symbol  GRK6
Synonyms  FLJ32135|GPRK6
Description  G protein-coupled receptor kinase 6
See related  HGNC:4545|MIM:600869|Ensembl:ENSG00000198055|HPRD:02925|
Locus tag  -
Gene type  protein-coding
Map location  5q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADAR0.880.90
LARP10.870.90
EIF2AK40.860.88
KIAA01000.860.89
LARP4B0.860.89
MTOR0.850.88
PRDM40.850.88
HLCS0.850.86
CLCN60.850.87
KPNA60.840.88
Top 10 negatively co-expressed genes
AF347015.21-0.68-0.68
AF347015.31-0.66-0.65
MT-CO2-0.64-0.64
HIGD1B-0.63-0.63
AF347015.8-0.63-0.63
AF347015.2-0.62-0.58
C1orf54-0.61-0.68
PLA2G5-0.60-0.61
FXYD1-0.60-0.58
MT-CYB-0.60-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0004703G-protein coupled receptor kinase activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionIEA-
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayTAS8077221 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surface-HPRD,BioGRID9819198 
CHRM3HM3cholinergic receptor, muscarinic 3-HPRD11856737 
EDNRBABCDS | ETB | ETBR | ETRB | HSCR | HSCR2endothelin receptor type B-HPRD9211925 
FSHRFSHRO | LGR1 | MGC141667 | MGC141668 | ODG1follicle stimulating hormone receptor-HPRD,BioGRID10379886 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD9826657 
PRSS23MGC5107 | SIG13 | SPUVE | ZSIG13protease, serine, 23Two-hybridBioGRID16169070 
RCVRNRCV1recoverin-HPRD,BioGRID12507501 
RHOCSNBAD1 | MGC138309 | MGC138311 | OPN2 | RP4rhodopsin-HPRD8366096 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)Biochemical ActivityBioGRID10852916 
SNCB-synuclein, betaBiochemical ActivityBioGRID10852916 
SNCGBCSG1 | SRsynuclein, gamma (breast cancer-specific protein 1)Biochemical ActivityBioGRID10852916 
TBXA2RTXA2-Rthromboxane A2 receptor-HPRD11504827 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
ODONNELL_METASTASIS_DN 2413All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SINGH_NFE2L2_TARGETS 1512All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_POOR_SURVIVAL_DN 2215All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206752758m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1377927981Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1812252311Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1928351A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-22171Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-34/449600606m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-409-3p751757m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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