Gene Page: GPT

Summary
GeneID  2875
Symbol  GPT
Synonyms  AAT1|ALT1|GPT1
Description  glutamic-pyruvate transaminase (alanine aminotransferase)
See related  HGNC:4552|MIM:138200|Ensembl:ENSG00000167701|HPRD:00689|
Locus tag  -
Gene type  protein-coding
Map location  8q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PRDM20.850.88
RAPGEF20.850.89
SBNO10.840.87
TEX20.840.87
PRKCE0.830.87
SDAD10.830.87
ADRBK20.830.88
CAMK1D0.830.85
UBP10.820.85
GRIA20.820.87
Top 10 negatively co-expressed genes
RHOC-0.63-0.69
AF347015.21-0.62-0.65
ENHO-0.61-0.71
S100A16-0.61-0.65
HIGD1B-0.61-0.64
AF347015.31-0.60-0.63
RAB34-0.60-0.65
MT-CO2-0.60-0.62
C1orf54-0.60-0.71
PLA2G5-0.60-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004021alanine transaminase activityEXPglutamate (GO term level: 6)9119391 
GO:0004021alanine transaminase activityNASglutamate (GO term level: 6)1931970 
GO:00168471-aminocyclopropane-1-carboxylate synthase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006094gluconeogenesisNAS-
GO:0009058biosynthetic processIEA-
GO:0006807nitrogen compound metabolic processNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9119391 
GO:0005737cytoplasmNAS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunitCAPN1 interacts with GPT.BIND12358155 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 3226All SZGR genes in this pathway
BIOCARTA_SARS_PATHWAY 105All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 1714All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON 15787All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
SU_LIVER 5532All SZGR genes in this pathway
SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_DN 2915All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN 17997All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
NAKAYAMA_FGF2_TARGETS 2917All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
MOOTHA_GLUCONEOGENESIS 3223All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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