Gene Page: GRID2

Summary
GeneID  2895
Symbol  GRID2
Synonyms  MGC117022|MGC117023|MGC117024
Description  glutamate receptor, ionotropic, delta 2
See related  HGNC:4576|MIM:602368|Ensembl:ENSG00000152208|HPRD:06781|
Locus tag  -
Gene type  protein-coding
Map location  4q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.638 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC7A60.880.85
NOL60.860.88
MFHAS10.860.83
SSBP30.850.90
SEZ60.840.81
CTNND20.840.81
RP1-21O18.10.840.79
LZTS10.830.79
PTPRS0.830.84
ZNF1420.830.84
Top 10 negatively co-expressed genes
SERPINB6-0.65-0.71
AF347015.31-0.61-0.74
AL139819.3-0.61-0.74
AF347015.27-0.61-0.76
MT-CO2-0.60-0.75
AF347015.33-0.60-0.73
BDH2-0.60-0.70
AF347015.8-0.59-0.75
MT-CYB-0.59-0.73
S100A16-0.58-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004970ionotropic glutamate receptor activityIEAglutamate (GO term level: 7)-
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0007215glutamate signaling pathwayTASglutamate (GO term level: 7)9465309 
GO:0035249synaptic transmission, glutamatergicIEAneuron, glutamate, Synap, Neurotransmitter (GO term level: 8)-
GO:0006811ion transportIEA-
GO:0060134prepulse inhibitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9465309 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EML1ELP79 | EMAP | EMAPL | FLJ45033 | HuEMAPechinoderm microtubule associated protein like 1-HPRD11829466 
GOPCCAL | FIG | GOPC1 | PIST | dJ94G16.2golgi associated PDZ and coiled-coil motif containingAffinity Capture-Western
Two-hybrid		BioGRID12372286 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1Affinity Capture-WesternBioGRID12573530 
GluR1 interacts with GluR-delta-2BIND12573530 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-WesternBioGRID12573530 
GRID2IPDELPHILINglutamate receptor, ionotropic, delta 2 (Grid2) interacting proteinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11826110 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2Affinity Capture-WesternBioGRID12573530 
GluR6 interacts with GluR-delta-2BIND12573530 
GRIK5EAA2 | GRIK2 | KA2glutamate receptor, ionotropic, kainate 5-HPRD,BioGRID12573530 
PTPN4PTPMEG | PTPMEG1protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)-HPRD,BioGRID10748123 
 
Pathway annotation


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