Gene Page: GRIK3

Summary
GeneID  2899
Symbol  GRIK3
Synonyms  EAA5|GLR7|GLUR7|GluR7a
Description  glutamate receptor, ionotropic, kainate 3
See related  HGNC:4581|MIM:138243|Ensembl:ENSG00000163873|HPRD:00691|
Locus tag  -
Gene type  protein-coding
Map location  1p34-p33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
QRICH20.910.89
ANO80.900.88
ADAMTS100.900.87
FBN30.900.84
AC145098.20.900.90
TRPV10.890.88
TAF1C0.890.87
RBM50.890.91
MAST20.890.90
KIAA0895L0.890.90
Top 10 negatively co-expressed genes
AF347015.31-0.66-0.80
AF347015.27-0.66-0.79
S100B-0.64-0.75
MT-CO2-0.64-0.79
TSC22D4-0.64-0.71
COPZ2-0.64-0.74
AIFM3-0.64-0.68
AF347015.33-0.63-0.76
ALDOC-0.63-0.65
HLA-F-0.63-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004970ionotropic glutamate receptor activityIEAglutamate (GO term level: 7)-
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0015277kainate selective glutamate receptor activityTASglutamate (GO term level: 8)7719709 
GO:0004872receptor activityIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007215glutamate signaling pathwayTASglutamate (GO term level: 7)7719709 
GO:0006811ion transportIEA-
GO:0042391regulation of membrane potentialIDA11124978 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS7719709 
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD11943148 
GRIK5EAA2 | GRIK2 | KA2glutamate receptor, ionotropic, kainate 5-HPRD,BioGRID9466455 
GRIP1GRIPglutamate receptor interacting protein 1Reconstituted Complex
Two-hybrid		BioGRID11891216 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1Reconstituted Complex
Two-hybrid		BioGRID11891216 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Reconstituted ComplexBioGRID11891216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 3123All SZGR genes in this pathway
REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 1111All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_NIMUSTINE 1713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-218249255m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.