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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GRIN2A

Summary

GeneID

2903

Symbol

GRIN2A

Synonyms

NMDAR2A|NR2A

Description

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Locus tag

Gene type

protein-coding

Map location

16p13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 15

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ZFP36

0.64

0.67

MT2A

0.62

0.61

CXCL1

0.61

0.53

SAT1

0.61

0.58

GADD45B

0.59

0.60

FOSL1

0.59

0.52

MT1F

0.59

0.50

TLCD1

0.59

MT1G

0.59

0.57

FXYD1

0.58

0.60

Top 10 negatively co-expressed genes

CSRP2BP

-0.54

-0.55

PPP2R2D

-0.53

-0.57

ARFGAP2

-0.53

PNMA1

-0.53

-0.56

WRNIP1

-0.52

-0.54

RAB1A

-0.52

-0.57

PSMD1

-0.52

-0.50

AC119673.2

-0.52

-0.51

FAM50B

-0.52

-0.54

BCL2L1

-0.52

-0.56

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004972

N-methyl-D-aspartate selective glutamate receptor activity

TAS

glutamate (GO term level: 8)

8768735

GO:0004970

ionotropic glutamate receptor activity

IEA

glutamate (GO term level: 7)

GO:0005234

extracellular-glutamate-gated ion channel activity

IEA

glutamate (GO term level: 11)

GO:0035254

glutamate receptor binding

IEA

glutamate (GO term level: 5)

GO:0000287

magnesium ion binding

IEA

GO:0004872

receptor activity

IEA

GO:0005509

calcium ion binding

IEA

GO:0005515

protein binding

IPI

17997397

GO:0005262

calcium channel activity

IEA

GO:0005216

ion channel activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0022008

neurogenesis

IEA

neurogenesis (GO term level: 6)

GO:0060079

regulation of excitatory postsynaptic membrane potential

IEA

neuron, Synap (GO term level: 10)

GO:0048167

regulation of synaptic plasticity

IEA

Synap (GO term level: 8)

GO:0007215

glutamate signaling pathway

TAS

glutamate (GO term level: 7)

8768735

GO:0030431

sleep

IEA

Brain (GO term level: 3)

GO:0042428

serotonin metabolic process

IEA

serotonin, Neurotransmitter (GO term level: 8)

GO:0042417

dopamine metabolic process

IEA

Neurotransmitter, dopamine (GO term level: 8)

GO:0001964

startle response

IEA

GO:0001975

response to amphetamine

IEA

GO:0008542

visual learning

IEA

GO:0009611

response to wounding

IEA

GO:0007613

memory

IEA

GO:0008104

protein localization

IEA

GO:0006816

calcium ion transport

IEA

GO:0006811

ion transport

IEA

GO:0042177

negative regulation of protein catabolic process

IEA

GO:0033058

directional locomotion

IEA

GO:0042493

response to drug

IEA

GO:0045471

response to ethanol

IDA

18445116

GO:0051930

regulation of sensory perception of pain

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0042734

presynaptic membrane

IEA

neuron, axon, Synap (GO term level: 5)

GO:0014069

postsynaptic density

IEA

Synap (GO term level: 10)

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0017146

N-methyl-D-aspartate selective glutamate receptor complex

IDA

glutamate, Synap (GO term level: 10)

10480938

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005737

cytoplasm

IDA

18029348

GO:0016021

integral to membrane

IEA

GO:0005886

plasma membrane

IEA

GO:0005887

integral to plasma membrane

TAS

8768735

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN1	FLJ40884	actinin, alpha 1	-	HPRD	11854440
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	-	HPRD,BioGRID	12933808
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	-	HPRD	10648730
DLG2		discs, large homolog 2, chapsyn-110 (Drosophila)	Two-hybrid	BioGRID	9278515
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	in vitro in vivo Two-hybrid	BioGRID	9278515 \|11937501
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	-	HPRD	11937501 \|12070168
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD	7569905 \|11937501 \|12419528
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	7569905 \|9278515 \|9286858 \|10648730 \|11937501 \|12419528
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	-	HPRD,BioGRID	9286858
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	Affinity Capture-Western Reconstituted Complex	BioGRID	9892651 \|10458595 \|12419528 \|12932824
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD	10458595 \|12932824
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	NR1a interacts with NR2A.	BIND	11279200
			-	HPRD	8139656 \|10862698 \|11803122 \|12068077 \|12191494 \|12893641 \|14732708
			Affinity Capture-Western	BioGRID	12391275
GRIN3B	NR3B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	Affinity Capture-Western	BioGRID	12008020
IL16	FLJ16806 \| FLJ42735 \| FLJ44234 \| HsT19289 \| IL-16 \| LCF \| prIL-16	interleukin 16 (lymphocyte chemoattractant factor)	npro-IL-16 interacts with NR2A.	BIND	12923170
IL16		interleukin 16 (lymphocyte chemoattractant factor)	-	HPRD,BioGRID	10479680
INADL	Cipp \| FLJ26982 \| InaD-like \| PATJ	InaD-like (Drosophila)	-	HPRD	9647694
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	11478920
PTPN4	PTPMEG \| PTPMEG1	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	-	HPRD,BioGRID	10748123
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD	12531901
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex	BioGRID	10458595 \|12932824
SRC	ASV \| SRC1 \| c-SRC \| p60-Src		-	HPRD	10458595 \|10884433 \|12932824

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	272	195	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE	169	110	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS	140	100	All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY	24	21	All SZGR genes in this pathway
PID_REELIN_PATHWAY	29	29	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	137	110	All SZGR genes in this pathway
REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR	17	15	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS	37	32	All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS	27	23	All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	33	28	All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION	15	14	All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII	15	14	All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN	175	82	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP	485	293	All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN	781	465	All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE	105	68	All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP	390	236	All SZGR genes in this pathway
WONG_IFNA2_RESISTANCE_DN	34	20	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN	337	230	All SZGR genes in this pathway
LU_AGING_BRAIN_DN	153	120	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN	97	53	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	536	296	All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3	590	403	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY	1839	928	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	904	910	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	904	910	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-137	416	423	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-19	142	149	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	142	149	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-381	911	917	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-431	656	662	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-7	166	172	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.