Gene Page: GRIN2B

Summary
GeneID  2904
Symbol  GRIN2B
Synonyms  MGC142178|MGC142180|NMDAR2B|NR2B|hNR3
Description  glutamate receptor, ionotropic, N-methyl D-aspartate 2B
See related  HGNC:4586|MIM:138252|Ensembl:ENSG00000150086|HPRD:00697|
Locus tag  -
Gene type  protein-coding
Map location  12p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 12 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31.1091 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityTASglutamate (GO term level: 8)8768735 
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0035254glutamate receptor bindingIEAglutamate (GO term level: 5)-
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI17047094 |17997397 
GO:0005262calcium channel activityIEA-
GO:0016594glycine bindingIDA17047094 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0048167regulation of synaptic plasticityIEASynap (GO term level: 8)-
GO:0007215glutamate signaling pathwayTASglutamate (GO term level: 7)8768735 
GO:0001701in utero embryonic developmentIEA-
GO:0001662behavioral fear responseIEA-
GO:0001964startle responseIEA-
GO:0001967suckling behaviorIEA-
GO:0009790embryonic developmentIEA-
GO:0007612learningIEA-
GO:0007613memoryIEA-
GO:0007423sensory organ developmentIEA-
GO:0006816calcium ion transportIEA-
GO:0006812cation transportIEA-
GO:0050966detection of mechanical stimulus involved in sensory perception of painIEA-
GO:0048266behavioral response to painIEA-
GO:0045471response to ethanolIDA18445116 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneIEAneuron, axon, Synap (GO term level: 5)-
GO:0008021synaptic vesicleIEASynap, Neurotransmitter (GO term level: 12)-
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIDAglutamate, Synap (GO term level: 10)10480938 |17047094 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8768735 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN2CMD1AAactinin, alpha 2-HPRD,BioGRID9009191 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alpha-HPRD,BioGRID11459059 
CAMK2N1MGC22256 | PRO1489 | RP11-401M16.1calcium/calmodulin-dependent protein kinase II inhibitor 1-HPRD12650977 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)Affinity Capture-WesternBioGRID11997254 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)Affinity Capture-Western
Two-hybrid		BioGRID9278515 |11997254 
-HPRD9806853 |11997254 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD,BioGRID11937501 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID7569905 |9278515 
|9581762 |11937501 
|11997254 |12738960 
-HPRD7569905 |9581762|11937501 
ERBB2IPERBIN | LAP2erbb2 interacting proteinReconstituted ComplexBioGRID11278603 
EXOC3SEC6 | SEC6L1 | Sec6pexocyst complex component 3Affinity Capture-WesternBioGRID12738960 
EXOC4MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8pexocyst complex component 4-HPRD,BioGRID12738960 
EXOC72-5-3p | DKFZp686J04253 | EX070 | EXO70 | EXOC1 | Exo70p | FLJ40965 | FLJ46415 | YJL085Wexocyst complex component 7Reconstituted ComplexBioGRID12738960 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID10458595 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID12524444 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1Affinity Capture-WesternBioGRID12391275 
-HPRD8139656 |12191494 
|15030493 
IL16FLJ16806 | FLJ42735 | FLJ44234 | HsT19289 | IL-16 | LCF | prIL-16interleukin 16 (lymphocyte chemoattractant factor)-HPRD,BioGRID10479680 
INADLCipp | FLJ26982 | InaD-like | PATJInaD-like (Drosophila)-HPRD9647694 
LIN7ALIN-7A | LIN7 | MALS-1 | MGC148143 | TIP-33 | VELI1lin-7 homolog A (C. elegans)in vitroBioGRID10341223 
LIN7BLIN-7B | MALS-2 | MALS2 | VELI2lin-7 homolog B (C. elegans)in vitro
in vivo		BioGRID10341223 
MAGI3MAGI-3 | MGC163281 | RP4-730K3.1 | dJ730K3.2membrane associated guanylate kinase, WW and PDZ domain containing 3-HPRD10748157 
MAGI3 interacts with NMDA receptor 2B.BIND10748157 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkin-HPRD,BioGRID11679592 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12531901 |12857875 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD10884433 
SYNGAP1DKFZp761G1421 | KIAA1938 | RASA1 | RASA5 | SYNGAPsynaptic Ras GTPase activating protein 1 homolog (rat)-HPRD9620694 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140100All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 1715All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 2723All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 3328All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 1514All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 1514All SZGR genes in this pathway
ROVERSI_GLIOMA_LOH_REGIONS 4430All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_UP 5340All SZGR genes in this pathway
CHESLER_BRAIN_QTL_CIS 7551All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
STEIN_ESR1_TARGETS 8555All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-204/211106410711A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-330124712541A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-4108458511Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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