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| GeneID |
2905
|
| Symbol |
GRIN2C
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| Synonyms |
NMDAR2C|NR2C
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| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| See related |
HGNC:4587|MIM:138254|Ensembl:ENSG00000161509|HPRD:00699| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
17q25 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 10 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| SOSTDC1 | 0.80 | 0.52 | | |
| CLDN1 | 0.71 | 0.37 | | |
| PROM1 | 0.70 | 0.34 | | |
| WNT11 | 0.70 | 0.37 | | |
| MYO16 | 0.68 | 0.41 | | |
| ADAMTSL3 | 0.67 | 0.44 | | |
| GDF10 | 0.67 | 0.58 | | |
| RASGEF1C | 0.65 | 0.39 | | |
| TAL2 | 0.63 | 0.21 | | |
| TRAF5 | 0.63 | 0.43 | | |
Top 10 negatively co-expressed genes | | REEP6 | -0.35 | -0.24 | | |
| RHBDL3 | -0.32 | -0.35 | | |
| NFE2L2 | -0.31 | -0.15 | | |
| FAM162A | -0.28 | -0.09 | | |
| NPC2 | -0.28 | -0.13 | | |
| RENBP | -0.28 | -0.11 | | |
| AIF1L | -0.28 | -0.19 | | |
| HLA-F | -0.28 | -0.05 | | |
| QPRT | -0.28 | -0.11 | | |
| GM2A | -0.28 | -0.16 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0004972 | N-methyl-D-aspartate selective glutamate receptor activity | IEA | glutamate (GO term level: 8) | - |
| GO:0004972 | N-methyl-D-aspartate selective glutamate receptor activity | TAS | glutamate (GO term level: 8) | 9798920 |
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | glutamate (GO term level: 11) | - |
| GO:0035254 | glutamate receptor binding | IEA | glutamate (GO term level: 5) | - |
| GO:0000287 | magnesium ion binding | IEA | | - |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0005509 | calcium ion binding | IEA | | - |
| GO:0005515 | protein binding | IEA | | - |
| GO:0005261 | cation channel activity | IEA | | - |
| GO:0005216 | ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060079 | regulation of excitatory postsynaptic membrane potential | IEA | neuron, Synap (GO term level: 10) | - |
| GO:0048167 | regulation of synaptic plasticity | IEA | Synap (GO term level: 8) | - |
| GO:0007215 | glutamate signaling pathway | TAS | glutamate (GO term level: 7) | 9798920 |
| GO:0009611 | response to wounding | IEA | | - |
| GO:0008104 | protein localization | IEA | | - |
| GO:0006811 | ion transport | IEA | | - |
| GO:0042177 | negative regulation of protein catabolic process | IEA | | - |
| GO:0042391 | regulation of membrane potential | IEA | | - |
| GO:0033058 | directional locomotion | IEA | | - |
| GO:0050885 | neuromuscular process controlling balance | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0014069 | postsynaptic density | IEA | Synap (GO term level: 10) | - |
| GO:0017146 | N-methyl-D-aspartate selective glutamate receptor complex | IEA | glutamate, Synap (GO term level: 10) | - |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0016021 | integral to membrane | IEA | | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0005887 | integral to plasma membrane | TAS | | 9798920 |
| GO:0030054 | cell junction | IEA | | - |
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