Gene Page: MED4

Summary
GeneID  29079
Symbol  MED4
Synonyms  DRIP36|FLJ10956|HSPC126|RP11-90M2.2|TRAP36|VDRIP
Description  mediator complex subunit 4
See related  HGNC:17903|MIM:605718|Ensembl:ENSG00000136146|HPRD:16145|
Locus tag  -
Gene type  protein-coding
Map location  13q14.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIDA12218053 
GO:0003712transcription cofactor activityIDA12218053 
GO:0005515protein bindingIPI17438371 
GO:0016455RNA polymerase II transcription mediator activityIDA10882111 
GO:0016563transcription activator activityIDA10198638 
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityNAS10235266 
GO:0042809vitamin D receptor bindingNAS10235266 
GO:0046966thyroid hormone receptor bindingIDA10198638 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterIDA12218053 
GO:0006350transcriptionIEA-
GO:0030521androgen receptor signaling pathwayIDA12218053 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000119mediator complexIDA10882111 
GO:0005634nucleusIDA10235267 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitTwo-hybridBioGRID16189514 
MCRS1ICP22BP | INO80Q | MCRS2 | MSP58 | P78microspherule protein 1Two-hybridBioGRID16189514 
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MS
Affinity Capture-Western		BioGRID14638676 |15175163 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MS
Affinity Capture-Western		BioGRID14638676 |15175163 
MED25ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758mediator complex subunit 25Affinity Capture-Western
Reconstituted Complex		BioGRID14638676 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MSBioGRID15175163 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29-HPRD14576168 
Affinity Capture-MS
Affinity Capture-Western		BioGRID14638676 |15175163 
MED30MGC9890 | THRAP6 | TRAP25mediator complex subunit 30TRAP36 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human TRAP36 and mouse TRAP25.BIND12584197 
Reconstituted ComplexBioGRID12584197 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9Affinity Capture-MSBioGRID15175163 
-HPRD14638676 
TNFAIP8GG2-1 | MDC-3.13 | SCC-S2 | SCCS2tumor necrosis factor, alpha-induced protein 8Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
LIU_VMYB_TARGETS_UP 12778All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX5_DN 85All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_DN 4134All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway


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