Gene Page: GRM8

Summary
GeneID  2918
Symbol  GRM8
Synonyms  FLJ41058|GLUR8|GPRC1H|MGC126724|MGLUR8|mGlu8
Description  glutamate receptor, metabotropic 8
See related  HGNC:4600|MIM:601116|Ensembl:ENSG00000179603|HPRD:03071|
Locus tag  -
Gene type  protein-coding
Map location  7q31.3-q32.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PPP2R5E0.970.97
DIS30.960.97
ZMYM40.960.97
WDR480.960.97
NUP1330.960.97
WDR30.960.97
SUPT16H0.950.96
EXOC20.950.97
STRN30.950.97
TAF20.950.96
Top 10 negatively co-expressed genes
AF347015.31-0.78-0.88
MT-CO2-0.78-0.89
FXYD1-0.76-0.86
AF347015.27-0.76-0.85
AF347015.33-0.76-0.85
AF347015.8-0.75-0.87
MT-CYB-0.75-0.85
IFI27-0.74-0.85
HIGD1B-0.73-0.85
AF347015.15-0.72-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001642group III metabotropic glutamate receptor activityIEAglutamate (GO term level: 8)-
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007194negative regulation of adenylate cyclase activityTAS9473604 
GO:0007165signal transductionIEA-
GO:0007608sensory perception of smellIEA-
GO:0007601visual perceptionTAS9473604 
GO:0050896response to stimulusIEA-
GO:0030818negative regulation of cAMP biosynthetic processIDA11166323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9473604 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD11943148 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS 1511All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_DN 8142All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-219971031Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-241461521Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-334464521Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-339281Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-3423403461Ahsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-3813753821A,m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-543504510m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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