Gene Page: GSS

Summary
GeneID  2937
Symbol  GSS
Synonyms  GSHS|MGC14098
Description  glutathione synthetase
See related  HGNC:4624|MIM:601002|Ensembl:ENSG00000100983|HPRD:03000|
Locus tag  -
Gene type  protein-coding
Map location  20q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C9orf230.790.77
C12orf620.780.72
ASPDH0.770.73
CISD30.770.70
NENF0.760.67
CBR10.760.78
COX4I10.760.69
UROD0.760.68
GPR1080.760.76
COX5B0.750.70
Top 10 negatively co-expressed genes
ZNF326-0.52-0.57
DAAM1-0.51-0.53
ANKRD12-0.51-0.53
NOL4-0.51-0.50
RTF1-0.51-0.53
RBM25-0.50-0.56
THOC2-0.50-0.56
ATXN7L1-0.50-0.50
LRRC7-0.50-0.49
C5orf42-0.50-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004363glutathione synthase activityTAS7646467 
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8896573 
GO:0006520amino acid metabolic processTAS8896573 
GO:0006750glutathione biosynthetic processIEA-
GO:0006979response to oxidative stressTAS465367 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLUTATHIONE_METABOLISM 5034All SZGR genes in this pathway
BIOCARTA_FREE_PATHWAY 107All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_GLUTATHIONE_CONJUGATION 2313All SZGR genes in this pathway
REACTOME_PHASE_II_CONJUGATION 7042All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON 3118All SZGR genes in this pathway
CHEOK_RESPONSE_TO_MERCAPTOPURINE_DN 2215All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 2515All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway


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