Gene Page: GTF2F1

Summary
GeneID  2962
Symbol  GTF2F1
Synonyms  BTF4|RAP74|TF2F1|TFIIF
Description  general transcription factor IIF, polypeptide 1, 74kDa
See related  HGNC:4652|MIM:189968|Ensembl:ENSG00000125651|HPRD:01803|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0721 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HOOK20.670.64
CEP2500.670.70
CEP1640.660.70
C17orf690.660.62
ANKS30.660.63
AGAP60.650.65
SFRS160.650.67
TRABD0.650.62
ZNF7850.640.63
PLCXD10.640.62
Top 10 negatively co-expressed genes
TM4SF1-0.43-0.46
B2M-0.43-0.47
C18orf32-0.42-0.46
CA4-0.42-0.46
LY96-0.42-0.53
MYL3-0.42-0.44
AC044839.2-0.41-0.43
AF347015.31-0.41-0.43
ITM2A-0.41-0.46
PLA2G4A-0.40-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0003677DNA bindingIEA-
GO:0003713transcription coactivator activityTAS7854423 
GO:0005515protein bindingIPI7590250 
GO:0016251general RNA polymerase II transcription factor activityTAS7854423 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006367transcription initiation from RNA polymerase II promoterTAS1734284 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
GO:0045941positive regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP1939271 |2449431 |8946909 
|9409616 |9512541 
|9790902 |12676794 
GO:0005674transcription factor TFIIF complexTAS1734283 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AHR-aryl hydrocarbon receptorReconstituted ComplexBioGRID8794892 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID9238003 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocatorReconstituted ComplexBioGRID8794892 
ATF7IPFLJ10139 | FLJ10688 | MCAF | p621activating transcription factor 7 interacting protein-HPRD10777215 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetCo-purificationBioGRID9159119 
CTDP1CCFDN | FCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1-HPRD,BioGRID9765293 |12732728 
CTDSP1NLIIF | SCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1-HPRD12721286 
FCP1FCP | FCPXF-cell production 1Reconstituted ComplexBioGRID12732728 
FEZ1-fasciculation and elongation protein zeta 1 (zygin I)Two-hybridBioGRID16169070 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologReconstituted ComplexBioGRID8628277 
GTF2A1MGC129969 | MGC129970 | TF2A1 | TFIIAgeneral transcription factor IIA, 1, 19/37kDa-HPRD,BioGRID11509574 
GTF2BTF2B | TFIIBgeneral transcription factor IIBCo-purification
Reconstituted Complex		BioGRID8662660 |9159119 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDaCo-purification
Reconstituted Complex		BioGRID7926747 |9159119 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDaReconstituted ComplexBioGRID9677423 |11113176 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD8441635 
GTF2H4TFB2 | TFIIHgeneral transcription factor IIH, polypeptide 4, 52kDaCo-purification
Reconstituted Complex		BioGRID9159119 
HNRNPUHNRPU | SAF-A | U21.1heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)Affinity Capture-WesternBioGRID10490622 
IRF1IRF-1 | MARinterferon regulatory factor 1TFIIF interacts with IRF-1 promoter.BIND15893730 
JUNAP-1 | AP1 | c-Junjun oncogeneReconstituted ComplexBioGRID8628277 
KLF5BTEB2 | CKLF | IKLFKruppel-like factor 5 (intestinal)Reconstituted ComplexBioGRID9089417 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-Western
Co-purification		BioGRID9159119 |9315662 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD,BioGRID9265625 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID8755740 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaCo-fractionation
Co-purification
Reconstituted Complex		BioGRID9159119 |9710619 
PSMC2MGC3004 | MSS1 | Nbla10058 | S7proteasome (prosome, macropain) 26S subunit, ATPase, 2-HPRD11118325 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinTwo-hybridBioGRID16169070 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD,BioGRID7854423 |8106390 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDaBiochemical Activity
in vitro
in vivo
Reconstituted Complex		BioGRID7590250 |8625415 
|9482861 |9660973 
|9858607 
-HPRD7590250 |8625415 
|9660973 |10428810 
TAF11MGC:15243 | PRO2134 | TAF2I | TAFII28TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDaCo-purification
Reconstituted Complex		BioGRID9159119 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinBiochemical Activity
Co-purification
Reconstituted Complex		BioGRID7590250 |9159119 
|9482861 
TCEA1GTF2S | SII | TCEA | TF2S | TFIIStranscription elongation factor A (SII), 1Reconstituted ComplexBioGRID9305922 
 


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