Gene Page: GUCY1B3

Summary
GeneID  2983
Symbol  GUCY1B3
Synonyms  GC-S-beta-1|GC-SB3|GUC1B3|GUCB3|GUCSB3|GUCY1B1
Description  guanylate cyclase 1, soluble, beta 3
See related  HGNC:4687|MIM:139397|HPRD:00769|
Locus tag  -
Gene type  protein-coding
Map location  4q31.3-q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.427 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GJD20.520.45
PRSS360.520.42
SLC29A30.510.45
C15orf270.510.49
KLHL310.500.29
FAM83G0.500.26
SHD0.490.44
SH2D3A0.490.22
ALK0.490.38
FAM43B0.490.45
Top 10 negatively co-expressed genes
KLKB1-0.21-0.13
AL139819.3-0.21-0.19
AF347015.18-0.21-0.09
AIF1L-0.21-0.13
AF347015.2-0.20-0.11
MT-CYB-0.20-0.11
MT-CO2-0.20-0.11
CWF19L2-0.20-0.25
MT-ATP8-0.20-0.12
AF347015.8-0.19-0.11
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9742212 
GO:0005506iron ion bindingIEA-
GO:0004383guanylate cyclase activityTAS9742212 
GO:0020037heme bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007263nitric oxide mediated signal transductionTAS9742212 
GO:0006182cGMP biosynthetic processIEA-
GO:0008015blood circulationTAS9742212 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0008074guanylate cyclase complex, solubleTAS1352257 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGAP1CENTG2 | GGAP1 | KIAA1099 | MGC71657ArfGAP with GTPase domain, ankyrin repeat and PH domain 1-HPRD15381706 
GUCY1A2GC-SA2 | GUC1A2guanylate cyclase 1, soluble, alpha 2-HPRD,BioGRID11572861 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID12676772 
NOS3ECNOS | eNOSnitric oxide synthase 3 (endothelial cell)Affinity Capture-Western
Reconstituted Complex		BioGRID12676772 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 2519All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN 7746All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_DN 230115All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
EHRLICH_ICF_SYNDROM_UP 138All SZGR genes in this pathway
GEORGANTAS_HSC_MARKERS 7147All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_INTRATHYMIC_T_PROGENITOR 2114All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_UP 11264All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP 11868All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_6 2920All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway


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