Gene Page: KCNIP3

Summary
GeneID  30818
Symbol  KCNIP3
Synonyms  CSEN|DREAM|KCHIP3|MGC18289
Description  Kv channel interacting protein 3, calsenilin
See related  HGNC:15523|MIM:604662|Ensembl:ENSG00000115041|HPRD:05232|
Locus tag  -
Gene type  protein-coding
Map location  2q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
ExpressionExpressionP value: 1.492 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA20130.810.81
RNH10.790.80
C3orf390.790.80
SCYL10.780.78
GRINA0.770.77
LRRC140.770.75
DOHH0.770.78
ZNF4440.760.81
C11orf680.760.76
ATG4D0.760.77
Top 10 negatively co-expressed genes
AF347015.21-0.46-0.38
NSBP1-0.43-0.44
AL139819.3-0.43-0.43
EIF5B-0.41-0.45
AC010300.1-0.41-0.48
AC090186.1-0.41-0.39
MT-ATP8-0.41-0.34
AC005921.3-0.40-0.44
FAM159B-0.40-0.57
SYCP3-0.39-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingTAS10078534 
GO:0003714transcription corepressor activityTAS10078534 
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS10900016 
GO:0005244voltage-gated ion channel activityIEA-
GO:0005267potassium channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS10078534 
GO:0006350transcriptionIEA-
GO:0007165signal transductionTAS10900016 
GO:0006811ion transportIEA-
GO:0006813potassium ion transportIEA-
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD11278424 
CD177HNA2A | NB1 | PRV1CD177 moleculeTwo-hybridBioGRID16189514 
CREB1CREB | MGC9284cAMP responsive element binding protein 1-HPRD,BioGRID12198160 
CREMICER | MGC111110 | MGC17881 | MGC41893 | hCREM-2cAMP responsive element modulator-HPRD,BioGRID11094064 |12198160 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-WesternBioGRID10854253 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Affinity Capture-WesternBioGRID9771752 |10854253 
-HPRD12207970 
PSEN2AD3L | AD4 | PS2 | STM2presenilin 2 (Alzheimer disease 4)-HPRD,BioGRID9771752 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_DREAM_PATHWAY 1413All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K27ME3 7035All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
MIKKELSEN_NPC_LCP_WITH_H3K4ME3 5834All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_PROGENITOR_DN 149All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206148414911A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-125/351172617331A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-218126212691A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-409-3p125312601A,m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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