Gene Page: HNF4A

Summary
GeneID  3172
Symbol  HNF4A
Synonyms  FLJ39654|HNF4|HNF4a7|HNF4a8|HNF4a9|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14
Description  hepatocyte nuclear factor 4, alpha
See related  HGNC:5024|MIM:600281|Ensembl:ENSG00000101076|HPRD:02612|
Locus tag  -
Gene type  protein-coding
Map location  20q12-q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TOP10.970.97
HNRNPR0.970.97
SFPQ0.970.96
SYNCRIP0.970.97
NCL0.960.96
THRAP30.960.96
HNRNPD0.960.96
SMC30.960.96
SUPT16H0.960.96
CTCF0.960.96
Top 10 negatively co-expressed genes
AF347015.31-0.75-0.91
MT-CO2-0.73-0.90
FXYD1-0.73-0.88
C5orf53-0.73-0.77
IFI27-0.73-0.88
HLA-F-0.73-0.79
AF347015.27-0.72-0.86
S100B-0.72-0.82
AF347015.33-0.71-0.86
AIFM3-0.71-0.77
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIDANeurotransmitter (GO term level: 4)12220494 
GO:0003700transcription factor activityIDA7615825 
GO:0003707steroid hormone receptor activityIEA-
GO:0005496steroid bindingIEA-
GO:0005504fatty acid bindingIDA12220494 
GO:0008270zinc ion bindingIEA-
GO:0042803protein homodimerization activityIDA12220494 
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterIMP17827783 
GO:0008285negative regulation of cell proliferationIMP18163890 
GO:0007596blood coagulationIDA12911579 
GO:0006805xenobiotic metabolic processIMP17827783 
GO:0006591ornithine metabolic processIMP17827783 
GO:0019216regulation of lipid metabolic processIDA10551874 
GO:0030308negative regulation of cell growthIMP18163890 
GO:0055088lipid homeostasisIMP17827783 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA18029348 
GO:0005634nucleusIDA7615825 
GO:0005737cytoplasmIDA14563941 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorCo-localizationBioGRID12944908 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCBP interacts with the HNF-4 gene.BIND15616580 
-HPRD,BioGRID9434765 |10085149 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-Western
Reconstituted Complex		BioGRID12944908 
ELP3FLJ10422 | KAT9elongation protein 3 homolog (S. cerevisiae)Elp3 interacts with the HNF-4 gene.BIND15616580 
EXT2SOTVexostoses (multiple) 2Affinity Capture-MSBioGRID17353931 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1-HPRD,BioGRID12519792 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AH3F3A (Histone 3) interacts with the HNF4A gene.BIND15616580 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD9792724 
MECRCGI-63 | FASN2B | NRBF1mitochondrial trans-2-enoyl-CoA reductase-HPRD9795230 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1-HPRD,BioGRID12089346 
MED14CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170mediator complex subunit 14-HPRD,BioGRID12101254 
MED23CRSP130 | CRSP133 | CRSP3 | DKFZp434H0117 | DRIP130 | SUR2mediator complex subunit 23Affinity Capture-WesternBioGRID12089346 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID9812974 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2-HPRD,BioGRID9812974 
NR0B2FLJ17090 | SHP | SHP1nuclear receptor subfamily 0, group B, member 2Reconstituted Complex
Two-hybrid		BioGRID10594021 
NR2C2TAK1 | TR2R1 | TR4 | hTAK1nuclear receptor subfamily 2, group C, member 2-HPRD,BioGRID12522137 
NR2F1COUP-TFI | EAR-3 | EAR3 | ERBAL3 | NR2F2 | SVP44 | TCFCOUP1 | TFCOUP1nuclear receptor subfamily 2, group F, member 1-HPRD10652338 
NRBF2COPR1 | COPR2 | DKFZp564C1664 | FLJ30395 | NRBF-2nuclear receptor binding factor 2-HPRD,BioGRID10786636 
PABPC4APP-1 | APP1 | FLJ43938 | PABP4 | iPABPpoly(A) binding protein, cytoplasmic 4 (inducible form)Affinity Capture-MSBioGRID17353931 
PPARGC1BERRL1 | PERC | PGC-1(beta) | PGC1Bperoxisome proliferator-activated receptor gamma, coactivator 1 beta-HPRD,BioGRID11733490 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD11229886 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Brg-1 interacts with the HNF-4 gene.BIND15616580 
SNCGBCSG1 | SRsynuclein, gamma (breast cancer-specific protein 1)Affinity Capture-MSBioGRID17353931 
STK16FLJ39635 | KRCT | MPSK | PKL12 | TSF1serine/threonine kinase 16Affinity Capture-MSBioGRID17353931 
SUB1MGC102747 | P15 | PC4 | p14SUB1 homolog (S. cerevisiae)-HPRD,BioGRID11741883 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11818510 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD9115274 
ZNHIT3TRIP3zinc finger, HIT type 3-HPRD,BioGRID11916906 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 2519All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 4936All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LUCAS_HNF4A_TARGETS_UP 5836All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_DN 4430All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
ZHOU_PANCREATIC_EXOCRINE_PROGENITOR 1110All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_DN 3121All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN 17997All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_VINCRISTINE 1910All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_VINBLASTINE 1812All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_UP 11264All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP 11868All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway


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