Gene Page: APBB1

Summary
GeneID  322
Symbol  APBB1
Synonyms  FE65|MGC:9072|RIR
Description  amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
See related  HGNC:581|MIM:602709|Ensembl:ENSG00000166313|HPRD:04087|
Locus tag  -
Gene type  protein-coding
Map location  11p15
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4398 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001540beta-amyloid bindingISS-
GO:0001540beta-amyloid bindingNAS8894693 
GO:0008134transcription factor bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0007409axonogenesisNASneuron, axon, neurite (GO term level: 12)12843239 
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0007165signal transductionNAS8894693 
GO:0007050cell cycle arrestISS-
GO:0008542visual learningIEA-
GO:0030308negative regulation of cell growthISS-
GO:0030198extracellular matrix organizationIEA-
GO:0045749negative regulation of S phase of mitotic cell cycleISS-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050760negative regulation of thymidylate synthase biosynthetic processISS-
GO:0045449regulation of transcriptionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030426growth coneIDAaxon, dendrite (GO term level: 5)12843239 
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0045202synapseIDAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)12843239 
GO:0045202synapseISSneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005634nucleusISS-
GO:0030027lamellipodiumIDA12843239 
GO:0030027lamellipodiumISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD11279131 
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1X11alpha interacts with APP.BIND11115513 
APLP1APLPamyloid beta (A4) precursor-like protein 1-HPRD8894693 
Reconstituted ComplexBioGRID10081969 
APLP2APPH | APPL2 | CDEBPamyloid beta (A4) precursor-like protein 2Affinity Capture-Western
Reconstituted Complex
BioGRID8855266 |10081969 
-HPRD8894693 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor proteinAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID8855266 |8887653 
|9045663 |9837937 
|10081969 
-HPRD8887653 |8955346 
|9045663 |9799084 
|9837937 |11085987 
CLSTN1ALC-ALPHA | CSTN1 | FLJ32258 | KIAA0911 | PIK3CD | XB31alpha | alcalpha1 | alcalpha2calsyntenin 1-HPRD15037614 
EVLRNB6Enah/Vasp-like-HPRD,BioGRID10945997 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD11741599 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5-HPRD12888553 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID9837937 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD9837937 
PRNPASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prionprion protein-HPRD15146195 
TFCP2CP2 | LBP-1C | LSF | SEF | TFCP2Ctranscription factor CP2-HPRD,BioGRID9685356 
 


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