Gene Page: APCS

Summary
GeneID  325
Symbol  APCS
Synonyms  MGC88159|PTX2|SAP
Description  amyloid P component, serum
See related  HGNC:584|MIM:104770|Ensembl:ENSG00000132703|HPRD:00101|
Locus tag  -
Gene type  protein-coding
Map location  1q21-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ILF20.970.96
EIF3F0.970.95
QARS0.960.95
EIF3L0.960.95
EIF3D0.960.93
SNRNP400.960.93
NUP880.960.94
PCBP20.960.94
RBMX0.950.94
SSR20.950.94
Top 10 negatively co-expressed genes
AF347015.27-0.70-0.88
AF347015.33-0.69-0.89
HLA-F-0.69-0.78
AF347015.31-0.69-0.85
MT-CO2-0.69-0.86
MT-CYB-0.69-0.88
AIFM3-0.68-0.77
AF347015.8-0.67-0.88
C5orf53-0.67-0.73
AF347015.15-0.66-0.88
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005529sugar bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0051082unfolded protein bindingTAS10812074 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006457protein foldingTAS10812074 
GO:0006953acute-phase responseTAS2987268 
GO:0051131chaperone-mediated protein complex assemblyTAS10972085 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceTAS10972085 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCSMGC88159 | PTX2 | SAPamyloid P component, serum-HPRD,BioGRID8114934 
C1QA-complement component 1, q subcomponent, A chain-HPRD8417122 
C4BPAC4BP | PRPcomplement component 4 binding protein, alpha-HPRD,BioGRID7592941 
CALUFLJ90608calumenin-HPRD,BioGRID10631319 
CRPMGC149895 | MGC88244 | PTX1C-reactive protein, pentraxin-related-HPRD,BioGRID1477104|8144569 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)Reconstituted ComplexBioGRID11359830 
FCGR3ACD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3Fc fragment of IgG, low affinity IIIa, receptor (CD16a)-HPRD,BioGRID11359830 
FCGR3BCD16 | CD16b | FCG3 | FCGR3Fc fragment of IgG, low affinity IIIb, receptor (CD16b)Reconstituted ComplexBioGRID11359830 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD,BioGRID12100475 
TGAITD3 | TGNthyroglobulin-HPRD3211159 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_AMYLOIDS 8363All SZGR genes in this pathway
FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_UP 108All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
SU_LIVER 5532All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
CHEN_LIVER_METABOLISM_QTL_CIS 9340All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_POOR_SURVIVAL 169All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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