Gene Page: HSD3B2

Summary
GeneID  3284
Symbol  HSD3B2
Synonyms  HSDB|HSDB3
Description  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
See related  HGNC:5218|MIM:201810|Ensembl:ENSG00000203859|HPRD:01941|
Locus tag  -
Gene type  protein-coding
Map location  1p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HSPA1A0.980.75
DNAJB10.920.68
HSPA60.910.62
G0S20.800.25
BAG30.770.27
AL031847.10.650.11
ACRC0.610.18
HSPB10.600.25
SERPINH10.550.46
GPR840.540.23
Top 10 negatively co-expressed genes
MFSD5-0.220.01
C20orf160-0.21-0.22
CDC42EP2-0.21-0.05
CLEC14A-0.20-0.17
MYLK2-0.19-0.13
LTC4S-0.19-0.36
AF205589.2-0.19-0.15
ACVRL1-0.19-0.02
CMTM8-0.19-0.34
C19orf39-0.19-0.11
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIDA1944309 
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIEA-
GO:0005488bindingIEA-
GO:0004769steroid delta-isomerase activityIDA1944309 
GO:0016853isomerase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006700C21-steroid hormone biosynthetic processIEA-
GO:0006694steroid biosynthetic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeISS-
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneISS-
GO:0005758mitochondrial intermembrane spaceISS-
GO:0005783endoplasmic reticulumNAS1944309 
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS1944309 
GO:0030868smooth endoplasmic reticulum membraneISS-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_STEROID_HORMONE_BIOSYNTHESIS 5530All SZGR genes in this pathway
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 3523All SZGR genes in this pathway
REACTOME_ANDROGEN_BIOSYNTHESIS 108All SZGR genes in this pathway
REACTOME_STEROID_HORMONES 2921All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_MARKERS_DN 2014All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_DN 7445All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_DN 3720All SZGR genes in this pathway


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