Gene Page: HTR1A

Summary
GeneID  3350
Symbol  HTR1A
Synonyms  5-HT1A|5HT1a|ADRB2RL1|ADRBRL1
Description  5-hydroxytryptamine (serotonin) receptor 1A
See related  HGNC:5286|MIM:109760|Ensembl:ENSG00000178394|HPRD:00190|
Locus tag  -
Gene type  protein-coding
Map location  5q11.2-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.457 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004993serotonin receptor activityTASserotonin, Neurotransmitter (GO term level: 8)9736659 
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS1330092 
GO:0007165signal transductionIEA-
GO:0008284positive regulation of cell proliferationTAS1330092 
GO:0007610behaviorTAS9736659 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS3138543 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GABBR2FLJ36928 | GABABR2 | GPR51 | GPRC3B | HG20 | HRIHFB2099gamma-aminobutyric acid (GABA) B receptor, 25-HT1A interacts with GABAB2. This interaction was modeled on a demonstrated interaction between 5-HT1A and GABAB2 from an unspecified species.BIND11854302 
GABRB2MGC119386 | MGC119388 | MGC119389gamma-aminobutyric acid (GABA) A receptor, beta 2-HPRD11854302 
GPR26MGC138216G protein-coupled receptor 26-HPRD,BioGRID11854302 
5-HT1A interacts with GPR26. This interaction was modeled on a demonstrated interaction between 5-HT1A and GPR26 from an unspecified species.BIND11854302 
HTR1A5-HT1A | 5HT1a | ADRB2RL1 | ADRBRL15-hydroxytryptamine (serotonin) receptor 1A5-HT1A homodimerizes. This interaction was modeled on a demonstrated interaction between two 5-HT1A proteins from an unspecified species.BIND11854302 
-HPRD11854302 
HTR1B5-HT1B | 5-HT1DB | HTR1D2 | HTR1DB | S125-hydroxytryptamine (serotonin) receptor 1B-HPRD11854302 
5-HT1A interacts with 5-HT1B. This interaction was modeled on a demonstrated interaction between 5-HT1A and 5-HT1B from an unspecified species.BIND11854302 
HTR1D5-HT1D | HT1DA | HTR1DA | HTRL | RDC45-hydroxytryptamine (serotonin) receptor 1D-HPRD,BioGRID11854302 
5-HT1A interacts with 5-HT1D. This interaction was modeled on a demonstrated interaction between 5-HT1A and 5-HT1D from an unspecified species.BIND11854302 
S1PR1CHEDG1 | D1S3362 | ECGF1 | EDG-1 | EDG1 | FLJ58121 | S1P1sphingosine-1-phosphate receptor 1-HPRD,BioGRID11854302 
5-HT1A interacts with EDG1. This interaction was modeled on a demonstrated interaction between 5-HT1A and EDG1 from an unspecified species.BIND11854302 
S1PR3EDG-3 | EDG3 | FLJ37523 | FLJ93220 | LPB3 | MGC71696 | S1P3sphingosine-1-phosphate receptor 35-HT1A interacts with EDG3. This interaction was modeled on a demonstrated interaction between 5-HT1A and EDG3 from an unspecified species.BIND11854302 
-HPRD,BioGRID11854302 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_SEROTONIN_RECEPTORS 1211All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER 2821All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_DN 2516All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3 7959All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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