Gene Page: APOE

Summary
GeneID  348
Symbol  APOE
Synonyms  AD2|LPG|MGC1571|apoprotein
Description  apolipoprotein E
See related  HGNC:613|MIM:107741|Ensembl:ENSG00000130203|HPRD:00135|
Locus tag  -
Gene type  protein-coding
Map location  19q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31.2393 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
APLP20.930.92
SV2A0.910.91
MAGEE10.900.92
DCTN10.900.90
STXBP10.900.90
WARS0.900.89
MADD0.900.89
DPP60.890.91
NFE2L10.890.89
CLSTN10.890.91
Top 10 negatively co-expressed genes
AF347015.21-0.56-0.43
C1orf61-0.56-0.61
C1orf54-0.54-0.49
GNG11-0.54-0.47
AP002478.3-0.54-0.50
HIGD1B-0.51-0.42
PLA2G5-0.50-0.38
AF347015.31-0.50-0.42
RAB34-0.50-0.53
MT-CO2-0.50-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001540beta-amyloid bindingIDA11305869 
GO:0005543phospholipid bindingIDA4066713 
GO:0005319lipid transporter activityIEA-
GO:0008201heparin bindingIEA-
GO:0008289lipid bindingIEA-
GO:0008034lipoprotein bindingIEA-
GO:0017127cholesterol transporter activityIEA-
GO:0016209antioxidant activityIDA9685360 
GO:0042803protein homodimerization activityIDA8245722 
GO:0046911metal chelating activityIDA9685360 
GO:0048156tau protein bindingIPI7566652 
GO:0050749apolipoprotein E receptor bindingIDA1384047 
GO:0050749apolipoprotein E receptor bindingIPI12950167 
GO:0046982protein heterodimerization activityIPI8245722 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007271synaptic transmission, cholinergicTASneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)9622609 
GO:0030516regulation of axon extensionTASaxon (GO term level: 14)9622609 
GO:0048168regulation of neuronal synaptic plasticityTASneuron, Synap (GO term level: 9)9622609 
GO:0000302response to reactive oxygen speciesNAS11743999 
GO:0001937negative regulation of endothelial cell proliferationIDA9685360 
GO:0007186G-protein coupled receptor protein signaling pathwayIDA16443932 
GO:0007263nitric oxide mediated signal transductionIDA8995232 
GO:0010544negative regulation of platelet activationIDA8995232 
GO:0006917induction of apoptosisIDA12753088 
GO:0007010cytoskeleton organizationTAS9622609 
GO:0006707cholesterol catabolic processIEA-
GO:0006979response to oxidative stressIEA-
GO:0006641triacylglycerol metabolic processIDA9649566 
GO:0006641triacylglycerol metabolic processIMP3771793 
GO:0006916anti-apoptosisIDA9685360 
GO:0006869lipid transportIEA-
GO:0006874cellular calcium ion homeostasisIEA-
GO:0042311vasodilationIEA-
GO:0033344cholesterol effluxIEA-
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA15950758 
GO:0051000positive regulation of nitric-oxide synthase activityIDA8995232 
GO:0034447very-low-density lipoprotein particle clearanceIMP9649566 
GO:0042158lipoprotein biosynthetic processIEA-
GO:0019934cGMP-mediated signalingIDA8995232 
GO:0030828positive regulation of cGMP biosynthetic processIDA8995232 
GO:0032805positive regulation of low-density lipoprotein receptor catabolic processIDA15950758 
GO:0034382chylomicron remnant clearanceIMP7175379 
GO:0032488Cdc42 protein signal transductionIDA16443932 
GO:0033700phospholipid effluxIDA11162594 
GO:0043407negative regulation of MAP kinase activityIDA9685360 
GO:0042632cholesterol homeostasisIEA-
GO:0046907intracellular transportTAS9622609 
GO:0050728negative regulation of inflammatory responseIC8995232 
GO:0043537negative regulation of blood vessel endothelial cell migrationIDA9685360 
GO:0043691reverse cholesterol transportIDA8127890 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaNASaxon, dendrite (GO term level: 4)8083695 
GO:0030425dendriteNASneuron, axon, dendrite (GO term level: 6)8083695 
GO:0005576extracellular regionEXP4345202 |8300609 
GO:0005576extracellular regionIEA-
GO:0005737cytoplasmTAS9622609 
GO:0005886plasma membraneEXP8300609 
GO:0034364high-density lipoprotein particleIDA210174 
GO:0034362low-density lipoprotein particleIDA8245722 
GO:0034363intermediate-density lipoprotein particleIDA17336988 
GO:0034361very-low-density lipoprotein particleIDA8245722 
GO:0042627chylomicronIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID9831625 
ALBDKFZp779N1935 | PRO0883 | PRO0903 | PRO1341albumin-HPRD8063017 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD10559559 
CNTFHCNTFciliary neurotrophic factorApolipoprotein E binds to ciliary neurotrophic factorBIND9236223 
CTSBAPPS | CPSBcathepsin B-HPRD12057992 
LDLRFH | FHClow density lipoprotein receptor-HPRD12036962 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD11421580 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD11421580 
Reconstituted ComplexBioGRID7768901 
LRP8APOER2 | HSZ75190 | MCI1low density lipoprotein receptor-related protein 8, apolipoprotein e receptor-HPRD,BioGRID12167620 |12950167 
MAP2DKFZp686I2148 | MAP2A | MAP2B | MAP2Cmicrotubule-associated protein 2-HPRD8624078 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tauReconstituted ComplexBioGRID8620924 
-HPRD7566652 |9147408 
NEFMNEF3 | NF-M | NFMneurofilament, medium polypeptideReconstituted ComplexBioGRID8620924 
PLTPHDLCQ9phospholipid transfer protein-HPRD,BioGRID12810820 
SCARB1CD36L1 | CLA-1 | CLA1 | MGC138242 | SR-BI | SRB1scavenger receptor class B, member 1-HPRD12138091 
SDC2HSPG | HSPG1 | SYND2syndecan 2-HPRD9869645 
VLDLRCHRMQ1 | FLJ35024 | VLDLRCHvery low density lipoprotein receptor-HPRD12167620 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 1512All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_UP 2614All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_UP 116All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_DN 3825All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN 14383All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP 8745All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP 5733All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP 7958All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
APPEL_IMATINIB_RESPONSE 3322All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
ABE_VEGFA_TARGETS_2HR 3421All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_UP 3824All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
ABE_VEGFA_TARGETS_30MIN 2921All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_UP 4940All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
LEIN_ASTROCYTE_MARKERS 4235All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN 3125All SZGR genes in this pathway
WEST_ADRENOCORTICAL_CARCINOMA_VS_ADENOMA_DN 2418All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_DN 5939All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP 4334All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
MELLMAN_TUT1_TARGETS_DN 4729All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
GERHOLD_RESPONSE_TO_TZD_DN 1311All SZGR genes in this pathway
ONGUSAHA_BRCA1_TARGETS_UP 1311All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_UP 3930All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_4_UP 1912All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_TOP20_UP 2014All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_UP 14675All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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